Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authordel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorCatania, Valentina
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorAarsland, Dag
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorGarn, Heinrich
dc.contributor.authorFraioli, Lucia
dc.contributor.authorPievani, Michela
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorde Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBaşar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek-Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorTaylor, John Paul
dc.contributor.authorde Pandis, Maria Francesca
dc.contributor.authorBonanni, Laura
dc.date.accessioned2021-01-18T12:26:54Z
dc.date.available2021-01-18T12:26:54Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractThe present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.
dc.description.sponsorshipH2020 Marie S. Curie ITN-ETN projecten_US
dc.identifier.citationBabiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Bonanni, L. (2018). Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases. Journal of Alzheimer's Disease, 62(1), 247-268. https://dx.doi.org/10.3233/JAD-170703
dc.identifier.doi10.3233/JAD-170703
dc.identifier.endpage268
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage247
dc.identifier.urihttps://dx.doi.org/10.3233/JAD-170703
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6279
dc.identifier.volume62
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIOS Press
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExact Low Resolution Brain Electromagnetic Source Tomography (Eloreta)
dc.subjectMild Cognitive Impairment Due to Alzheimer's Disease
dc.subjectMild Cognitive Impairment Due to Dementia With Lewy Bodies
dc.subjectReceiver Operating Characteristic Curve
dc.subjectResting State Electroencephalographic Rhythms
dc.titleAbnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases
dc.typeArticle

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