Momordica charantia enhances tendon healing in rats: an experimental study

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dc.authorid0000-0002-6984-3079
dc.contributor.authorErdoğan, Furkan
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorCoşkun, Hüseyin Sina
dc.contributor.authorAltun, Gamze
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorKelsaka, Ebru
dc.contributor.authorKaplan, Süleyman
dc.contributor.authorPişkin, Ahmet
dc.date.accessioned2024-09-19T13:54:20Z
dc.date.available2024-09-19T13:54:20Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractMomordica charantia (MC) is a traditional plant widely used since ancient times for wound healing. This study evaluated its potential effects on tendon healing. Adult male Wistar albino rats (n = 32, 8 rats in each group) were anesthetized, and their Achilles tendons were prepared for surgical procedures. Group 1 (Cont = control group) was not subjected to any surgery and was used as a control group for baseline values. Group 2 (PR = primary repair group) underwent primary repair (PR) with a monofilament suture after a full-thickness incision of the Achilles tendon. A full-thickness incision was also made to the Achilles tendon of group 3 (CT = collagen tube-administered group), followed by PR and collagen tube insertion. In group 4 (MC = M. charantia-administered group), 1 mL of MC extract was applied locally on the collagen tube in addition to the surgical procedure applied to group 3. The Achilles tendons were excised on the postoperative 40th day and examined stereologically, histologically, and bioinformatically. Data showed that the total volume of the collagen fibers was higher in MC and CT groups than in the PR group. The total volume of the tendon was decreased in MC and CT groups than in the Cont group. The ratios between the volumes of the collagen fibers and total tendon in the MC and CT groups were significantly different from PR, but not different from the Cont group. Additionally, MC improved tenoblastic activity, collagen production, and neovascularization. Bioinformatic interactions showed that the proteases of MC could trigger the signals playing a role on vasculogenesis, reducing inflammation, and contributing to tenoblast activation and collagen remodeling. MC extract ameliorates the healing of injured tendon and can provide satisfactory tendon repair. Further works are recommended to explore the healing capacity of MC.
dc.identifier.citationErdoğan, F., Kaplan, A. A., Coşkun, H. S., Altun, G., Altunkaynak, B. Z., Kelsaka, E. ... Pişkin, A. (2024). Momordica charantia enhances tendon healing in rats: an experimental study. Cells Tissues Organs, 213(4), 304-315. http://dx.doi.org/10.1159/000533644
dc.identifier.doi10.1159/000533644
dc.identifier.endpage315
dc.identifier.issn1422-6405
dc.identifier.issn1422-6421
dc.identifier.issue4
dc.identifier.pmid37586334
dc.identifier.scopus2-s2.0-85195033171
dc.identifier.scopusqualityQ2
dc.identifier.startpage304
dc.identifier.urihttp://dx.doi.org/10.1159/000533644
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12816
dc.identifier.volume213
dc.identifier.wos001049664300001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Arife Ahsen
dc.language.isoen
dc.relation.ispartofCells Tissues Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioinformatics
dc.subjectMomordica Charantia
dc.subjectRat
dc.subjectStereology
dc.subjectTendon Healing
dc.titleMomordica charantia enhances tendon healing in rats: an experimental study
dc.typeArticle

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