Factors associated with neurodevelopmental impairment in preterm infants with bronchopulmonary dysplasia

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dc.contributor.authorYazıcı, A.
dc.contributor.authorBüyüktiryaki, Mehmet
dc.contributor.authorŞimşek, G. K.
dc.contributor.authorKanmaz Kutman, Hatice Gözde
dc.contributor.authorCanpolat, Fuat Emre
dc.date.accessioned2022-04-01T07:40:35Z
dc.date.available2022-04-01T07:40:35Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Bronchopulmonary dysplasia (BPD) is a common and serious complication in preterm infants with very low birth weight and is known to lead to poor neurodevelopmental outcomes. This study aimed to identify factors associated with neurodevelopmental impairment (NDI) in patients with moderate to severe BPD. SUBJECTS AND METHODS: A total of 83 preterm infants born between 24- and 29-weeks' gestation who were admitted to the neonatal intensive care unit and developed moderate/severe BPD between 2013 and 2017 were retrospectively evaluated. Developmental assessment was performed at 18 to 24 months of corrected age using the Bayley Scales of Infant Development II (BSID-II). Patients with NDI (n=41) and without NDI (n=42) were compared. RESULTS: BSID-II Mental Development Index and Psychomotor Development Index scores were 87±11 and 83±8 in the non-NDI group and 57±12 and 52±8 in the NDI group, respectively (p<0.001). The NDI group had significantly lower birth weight (847±174 vs. 1012±192 g) and gestational age (26.1±1.3 and 27.6±1.6 weeks) compared to the non-NDI group (p<0.001). Intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, exposure to steroids, duration of respiratory support, and length of hospital stay were significantly higher in the NDI group (p<0.001). CONCLUSIONS: Many of the conditions in this study were found to be associated with poor neurodevelopmental outcomes in patients with BPD, such as prolonged respiratory support, prolonged hospitalization, intraventricular hemorrhage, retinopathy, and steroid therapy, can be avoided or prevented with strict protocols and prevention strategies. Appropriate management of comorbid risk factors may help prevent poor neurodevelopmental outcomes.
dc.identifier.citationYazıcı, A., Büyüktiryaki, M., Şimşek, G. K., Kanmaz Kutman, H. G. ve Canpolat, F. E. (2022). Factors associated with neurodevelopmental impairment in preterm infants with bronchopulmonary dysplasia. European Review for Medical and Pharmacological Sciences, 26(5), 1279-1285. https://doi.org/10.26355/eurrev_202203_28224
dc.identifier.doi10.26355/eurrev_202203_28224
dc.identifier.endpage1285
dc.identifier.issn1128-3602
dc.identifier.issue5
dc.identifier.pmid35302203
dc.identifier.scopus2-s2.0-85126713889
dc.identifier.scopusqualityQ2
dc.identifier.startpage1279
dc.identifier.urihttps://doi.org/10.26355/eurrev_202203_28224
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9193
dc.identifier.volume26
dc.identifier.wos000771549500021en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBüyüktiryaki, Mehmet
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBronchopulmonary Dysplasia
dc.subjectNeurodevelopmental Impairment
dc.subjectPrematurity
dc.titleFactors associated with neurodevelopmental impairment in preterm infants with bronchopulmonary dysplasia
dc.typeArticle

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