Transcranial direct current stimulation in the treatment of essential tremor: An open-label study

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dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-7566-1063
dc.contributor.authorYılmaz Helvacı, Nesrin
dc.contributor.authorPolat, Burcu
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:59Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:59Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000375144800004
dc.descriptionPubMed ID: 26926852
dc.description.abstractIntroduction: Pharmacotherapy and thalamic stimulation are the most accepted methods used for the treatment of essential tremor (ET). Transcranial direct current stimulation (tDCS) is a noninvasive method for brain stimulation, especially to treat pain, cerebrovascular disease, and depression. tDCS applied to the cerebellar region has been shown to exhibit a modulating effect on the excitability of Purkinje cells and to cause primary motor cortex inhibition through the regulation of synaptic dentato-thalamo-cortical excitability. There is only 1 trial that studied the effect of tDCS on ET with 8 patients, and the results were not satisfactory. Case Series: Six ET patients were administered the Essential Tremor Rating Assessment Scale (TETRAS) and Activities of Daily Living (ADL). We applied tDCS to the dorsolateral prefrontal areas (anode) and to inion (inion at 2 mA for 20 min in 10 consecutive sessions with a 2-d break between the first and the second 5-d sessions). One month after the initial course of therapy, 5 more tDCS sessions were administered in an every-other-day manner. TETRAS and ADL scales were readministered. The Friedman test was used to assess differences in TETRAS scores and ADL over the whole time course. Conclusions: A significant improvement was observed in TETRAS and ADL scores at the end of 50 days (P = 0.015, 0.024). We concluded that although our sample group is small, tDCS might be an alternative therapy for patients with ET.
dc.identifier.citationYılmaz Helvacı, N., Polat, B. ve Hanoğlu, L. (2016). Transcranial direct current stimulation in the treatment of essential tremor: An open-label study. Neurologist, 21(2), 28-29. https://dx.doi.org/10.1097/NRL.0000000000000070
dc.identifier.doi10.1097/NRL.0000000000000070
dc.identifier.endpage29
dc.identifier.issn1074-7931
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage28
dc.identifier.urihttps://dx.doi.org/10.1097/NRL.0000000000000070
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3516
dc.identifier.volume21
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofNeurologisten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEssential Tremor
dc.subjectNeuromodulation
dc.subjectTranscranial Direct Current Stimulation
dc.titleTranscranial direct current stimulation in the treatment of essential tremor: An open-label study
dc.typeArticle

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