Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration

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dc.authorid0000-0003-0039-3281
dc.authorid0000-0001-9192-5014
dc.authorid0000-0002-6393-1465
dc.authorid0000-0002-6637-9944
dc.authorid0000-0002-9476-8488
dc.authorid0000-0003-2562-1068
dc.authorid0000-0001-8656-7101
dc.authorid0000-0002-1222-9211
dc.contributor.authorBalçıkanlı, Zeynep
dc.contributor.authorÇulha, İrem
dc.contributor.authorDilsiz, Pelin
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorAteş, Nilay
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorKoç, Halil İbrahim
dc.contributor.authorYiğitbaşı, Ahmet
dc.contributor.authorGündoğar, Mustafa
dc.contributor.authorDoeppner, Thorsten Roland
dc.contributor.authorHermann, Dirk M.
dc.date.accessioned2022-12-09T11:37:54Z
dc.date.available2022-12-09T11:37:54Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalı
dc.description.abstractSpinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar mood disorder, lithium was reported to have neuroprotective activity in different neurodegenerative conditions, including SCI. In SCI, the effects of lithium on long-term neurological recovery and neuroplasticity have not been assessed. We herein investigated the effects of intraperitoneally administered lithium chloride (LiCl) on motor coordination recovery, electromyography (EMG) responses, histopathological injury and remodeling, and axonal plasticity in mice exposed to spinal cord transection. At a dose of 0.2, but not 2.0 mmol/kg, LiCl enhanced motor coordination and locomotor activity starting at 28 days post-injury (dpi), as assessed by a set of behavioral tests. Following electrical stimulation proximal to the hemitransection, LiCl at 0.2 mmol/kg decreased the latency and increased the amplitude of EMG responses in the denervated hindlimb at 56 dpi. Functional recovery was associated with reduced gray and white matter atrophy rostral and caudal to the hemitransection, increased neuronal survival and reduced astrogliosis in the dorsal and ventral horns caudal to the hemitransection, and increased regeneration of long-distance axons proximal and distal to the lesion site in mice receiving 0.2 mmol/kg, but not 2 mmol/kg LiCl, as assessed by histochemical and immunohistochemical studies combined with anterograde tract tracing. Our results indicate that LiCl induces long-term neurological recovery and neuroplasticity following SCI.
dc.description.sponsorshipTUBA ; Istanbul Medipol University ; Turkish Academy of Sciencesen_US
dc.identifier.citationBalçıkanlı, Z., Çulha, İ., Dilsiz, P., Aydın, M. Ş., Ateş, N., Beker, M. Ç. ... Hermann, D. M. (2022). Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.1012523
dc.identifier.doi10.3389/fncel.2022.1012523
dc.identifier.issn1662-5102
dc.identifier.pmid36439202
dc.identifier.scopus2-s2.0-85142652745
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fncel.2022.1012523
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10104
dc.identifier.volume16
dc.identifier.wos000890502600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalçıkanlı, Zeynep
dc.institutionauthorÇulha, İrem
dc.institutionauthorDilsiz, Pelin
dc.institutionauthorAydın, Mehmet Şerif
dc.institutionauthorAteş, Nilay
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorBaltacı, Saltuk Buğra
dc.institutionauthorKoç, Halil İbrahim
dc.institutionauthorGündoğar, Mustafa
dc.institutionauthorDoeppner, Thorsten Roland
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.relation.ispartofFrontiers in Cellular Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAxonal Plasticity
dc.subjectAxonal Regeneration
dc.subjectMotor Coordination
dc.subjectNeurological Recovery
dc.subjectSpinal Cord Hemitransection
dc.subjectSpinal Cord Trauma
dc.titleLithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration
dc.typeArticle

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