DR-70: A promising biomarker for the detection of lung cancer

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dc.authorid0000-0002-9569-6025
dc.contributor.authorÖzgül, Güler
dc.contributor.authorKoç, Aysu Sinem
dc.contributor.authorTuran, Demet
dc.contributor.authorKüçük, Suat Hayri
dc.contributor.authorÖzsoy, Şule
dc.contributor.authorBaydili, Kürşad Nuri
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorÖzgül, Mehmet Akif
dc.contributor.authorEğri Kansu, Zeynep
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.date.accessioned2021-12-10T09:07:04Z
dc.date.available2021-12-10T09:07:04Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Lung cancer (LC) is characterized by an aggressive phenotype with a high mortality rate, early metastasis, and proliferation rate. Treatment options and prognosis differ significantly at each stage. Despite the availability of multiple imaging studies and invasive procedures, the disorder is diagnosed at an advanced stage. Therefore, it is essential to find biomarkers for the early detection of LC. Patients and Methods: Between 2018 and 2020, 73 LC and 71 control with the same demographic characteristics were included in our study. DR-70 level was measured by a photometric method in serum samples taken from all subjects. Results: A total of 144 subjects (110 male, 34 female) was included in the study. DR-70 levels in the LC group (2.53 +/- 2.64 mu g/mL) were found to be statistically significantly higher than the control group (0.56 +/- 1.23 mu g/mL). Clinical sensitivity and specificity of DR-70 for LC were found to be 87.67% and 88.73%. Conclusions: The high sensitivity and specificity of DR-70 can be used as a biomarker for rapid diagnosis in patients with LC. Compared with other tumor biomarkers, DR-70 seems to have a better sensitivity and specificity in the diagnosis of LC.
dc.identifier.citationÖzgül, G., Koç, A. S., Turan, D., Küçük, S. H., Özsoy, S., Baydili, K. N. ... Seyhan, E. C. (2021). DR-70: A promising biomarker for the detection of lung cancer. World Cancer Research Journal, 8.
dc.identifier.issn2372-3416
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8636
dc.identifier.volume8
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofWorld Cancer Research Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectLung Cancer
dc.subjectDR-70
dc.subjectBiomarker
dc.subjectTumor Marker
dc.subjectEarly Diagnosis
dc.titleDR-70: A promising biomarker for the detection of lung cancer
dc.typeArticle

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