In-vivo corneal biomechanical analysis of unilateral keratoconus

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dc.contributor.authorAyar, Orhan
dc.contributor.authorÖzmen, Mehmet Cüneyt
dc.contributor.authorMüftüo?lu, Orkun
dc.contributor.authorAkdemir, Mehmet Orçun
dc.contributor.authorKoç, Mustafa
dc.contributor.authorÖzülken, Kemal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:43Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:43Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000364730200011
dc.descriptionPubMed ID: 26682162
dc.description.abstractAIM: To evaluate and compare corneal biomechanical findings measured by ocular response analyzer, topographic and pachymetric findings in patients with unilateral keratoconus patients and healthy controls. METHODS: This is an observational, case -control study. Patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with sex and age matched with controls healthy subjects. All subjects were evaluated with rotating scheimpflug imaging system. The receiver -operating -characteristic curves were analyzed to evaluate the sensitivity and specificity of the parameters. RESULTS: Twenty-seven patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with 40 eyes of 40 normal subjects. Corneal hysteresis (CH) was 8.0 +/- 1.7 mm Hg in keratoconus group, 8.3 +/- 1.6 mm Hg in forme fruste keratoconus group, and 9.8 +/- 1.6 mm Hg in control groups (P=0.54 between keratoconus and forme fruste keratoconus groups, P<0.01 between control group and other groups). Corneal resistance factor (CRF) was 7.1 +/- 2.2 mm Hg in keratoconus group, 7.8 +/- 1.2 mm Hg in forme fruste keratoconus group and 9.9 +/- 1.5 mm Hg in control group (P < 0.001 between control group and other groups). Using receiver-operating-characteristic analysis, the area under curve values of the parameters to distinguish forme fruste keratoconus from control subjects were: CH (0.768), CRF (0.866). Best cut-off points were 9.3 mm Hg and 8.8 mm Hg for CH and CRF respectively. CONCLUSION: Ocular response analyzer parameters (CH and CRF) are found to be significantly lower in forme fruste keratoconus patients compared to normal control subjects.
dc.identifier.citationAyar, O., Özmen, M. C., Müftüo?lu, O., Akdemir, M. O., Koç, M. ve Özülken, K. (2015). In-vivo corneal biomechanical analysis of unilateral keratoconus. International Journal of Ophthalmology, 8(6), 1141-1145. https://dx.doi.org/10.3980/j.issn.2222-3959.2015.06.11
dc.identifier.doi10.3980/j.issn.2222-3959.2015.06.11
dc.identifier.endpage1145
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage1141
dc.identifier.urihttps://dx.doi.org/10.3980/j.issn.2222-3959.2015.06.11
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2799
dc.identifier.volume8
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInternational Journal of Ophthalmology
dc.relation.ispartofInternational Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectForme Fruste Keratoconus
dc.subjectKeratoconus
dc.subjectOcular Response Analyzer
dc.titleIn-vivo corneal biomechanical analysis of unilateral keratoconus
dc.typeArticle

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