Surgery vs medical treatment in the management of PFAPA syndrome: A comparative trial

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dc.authorid0000-0002-6299-7067
dc.authorid0000-0002-8968-4079
dc.authorid0000-0003-4904-279X
dc.contributor.authorErdoğan, Fırat
dc.contributor.authorKulak, Kudret
dc.contributor.authorÖztürk, Özmen
dc.contributor.authorİpek Özahı, İlke
dc.contributor.authorCeran, Ömer
dc.contributor.authorSeven, Hüseyin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:20Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:20Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000390990500004
dc.descriptionPubMed ID: 26256936
dc.description.abstractBackground: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is a common disorder in children but there is little or no consensus on its optimal diagnosis and management.Objectives: To compare the outcome of different management approaches - medical therapy or tonsillectomy.Methods: The medical records of children diagnosed with PFAPA between 2008 and 2013 were retrospectively reviewed according to the modified Thomas test criteria. Patients were divided into two groups: group 1 for medical treatment - corticosteroids, a single intramuscular injection of methylprednisolone, and group 2 for surgery - tonsillectomy alone or tonsillectomy plus adenoidectomy .The course of the disease including the number and duration of episodes and the presence of remission, was documented.Results: 105 patients (30 in group 1, 75 in group 2) met the study's inclusion criteria. Groups 1 and 2 were followed up for a mean (SD) of 23.6 (11.0) and 24 (10.3) months, respectively. At the end of the follow-up period, the number of episodes was 5.8 (6.3) vs 1.8 (1.9) (P<0.01) and their duration was 2.2 (1.3) vs 1.1 (0.8) days (P=0.03), both of which were significantly lower in group 2.The need for hospitalization during this period was significantly lower for group 2 at 1.1 (2.0) vs 0.1 (0.3) (P<0.01) and the remission rate in group 2 was significantly higher than in group 1 (98.6% vs 56.6%, P<0.01).Conclusion: This study demonstrated that surgery is superior to medical treatment for PFAPA in terms of increased remission rates and a decrease in the number and duration of episodes.
dc.identifier.citationErdoğan, F., Kulak, K., Öztürk, Ö., İpek Özahı, İ., Ceran, Ö. ve Seven, H. (2016). Surgery vs medical treatment in the management of PFAPA syndrome: A comparative trial. Paediatrics And International Child Health, 36(4), 270-274. https://dx.doi.org/10.1179/2046905515Y.0000000051
dc.identifier.doi10.1179/2046905515Y.0000000051
dc.identifier.endpage274
dc.identifier.issn2046-9047
dc.identifier.issn2046-9055
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage270
dc.identifier.urihttps://dx.doi.org/10.1179/2046905515Y.0000000051
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3621
dc.identifier.volume36
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPaediatrics And International Child Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMedical Treatment
dc.subjectPeriodic Fever
dc.subjectPFAPA Syndrome
dc.subjectSurgery
dc.titleSurgery vs medical treatment in the management of PFAPA syndrome: A comparative trial
dc.typeArticle

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