Dosimetric evaluation of right coronary artery in radiotherapy for breast cancer

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dc.authorid0000-0002-0103-7683
dc.authorid0000-0003-3468-7712
dc.contributor.authorYıldırım Altınok, Ayşe
dc.contributor.authorAskeroğlu, Orbay
dc.contributor.authorDoyuran, Mine
dc.contributor.authorÇağlar, Mustafa
dc.contributor.authorCantürk, Emir
dc.contributor.authorErol, Cengiz
dc.contributor.authorŞenel Beşe, Nuran
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:41Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:41Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractComparison with control groups of untreated patients suggests that right-breast-cancer patients who receive radiotherapy have a higher rate of heart disease. Dose constraint for heart has been established to minimize radiotherapy-induced cardiotoxicity during left breast cancer treatment. Additionally, it is suggested to minimize the dosage on left anterior descending (LAD) artery. Right coronary artery (RCA), is the second largest artery, after left main coronary artery, supplying the heart. A dose evaluation study is not present for RCA; the proximal part of which is included in the irradiation field during breast cancer treatment of right breast. To investigate the presence of a correlation, doses resulting from right and left breast radiotherapy on proximal RCA (pRCA), LAD, and heart are evaluated in this study. Forty breast cancer patients who went under breast-conserving surgery are the subject of this study. Four groups were established; right breast, right breast and internal mammary (IM), left breast and left breast, and IM. pRCA, LAD, and heart volumes were contoured for each group on the planning tomographies. Resultant doses of tangential fields planning on these volumes were compared using dose-volume histograms. Mean and maximum doses of pRCA were statistically compared between groups. The highest mean and maximum point doses (192 to 284 cGy) were found in the right breast + IM group (p <0.05). The mean and maximum doses only in the right breast and left breast + IM group did not differ statistically. However, the mean and maximum pRCA doses in these 2 groups were higher than only the left breast group (p<0.05). pRCA receives high doses during radiotherapy of right and left breast especially if IM is included. This may predispose to coronary artery disease.
dc.identifier.citationYıldırım Altınok, A., Askeroğlu, O., Doyuran, M., Çağlar, M., Cantürk, E., Erol, C. ve Şenel Beşe, N. (2019). Dosimetric evaluation of right coronary artery in radiotherapy for breast cancer. Medical Dosimetry, 44(3), 205-209. https://dx.doi.org/10.1016/j.meddos.2018.06.006
dc.identifier.doi10.1016/j.meddos.2018.06.006
dc.identifier.endpage209
dc.identifier.issn0958-3947
dc.identifier.issn1873-4022
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage205
dc.identifier.urihttps://hdl.handle.net/20.500.12511/899
dc.identifier.urihttps://dx.doi.org/10.1016/j.meddos.2018.06.006
dc.identifier.volume44
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofMedical Dosimetryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast cancer
dc.subjectCardiotoxicity
dc.subjectRadiotherapy
dc.subjectRight Coronary Artery
dc.titleDosimetric evaluation of right coronary artery in radiotherapy for breast cancer
dc.typeArticle

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