Effects of benzoic acid synthesized from cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos

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dc.authorid0000-0002-6274-801X
dc.contributor.authorCansız, Derya
dc.contributor.authorÖzokan, Gökhan
dc.contributor.authorBilginer, Abdulkerim
dc.contributor.authorIşıkoğlu, Semanur
dc.contributor.authorMızrak, Zülal
dc.contributor.authorÜnal, İsmail
dc.contributor.authorBeler, Merih
dc.contributor.authorAlturfan, A. Ata
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2024-11-04T12:11:36Z
dc.date.available2024-11-04T12:11:36Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBenzoic acid, the most basic aromatic carboxylic acid, is produced industrially and used in cosmetic, hygiene, and pharmaceutical items as a flavoring ingredient and/or preservative. The significance of sodium benzoate, a metabolite of cinnamon, used as a food preservative and FDA-approved medication to treat urea cycle abnormalities in humans, has been shown to raise the levels of neurotrophic factors. Valproic acid (VPA), a commonly used anti-epileptic and mood-stabilizing medication, causes behavioral and intellectual problems and is a commonly used agent to induce animal model for autism. Aim of this study is to determine the effects of benzoic acid synthesized from Cinnamomum Cassia by green chemistry method on gene expressions related to autism development in case of VPA toxicity. Zebrafish embryos were exposed to low and high doses of benzoic acid for 72 h post-fertilization. Locomotor activities were determined. Acetylcholinesterase (AchE), lipid peroxidation, nitric oxide (NO), sialic acid (SA), glutathione (GSH)-S-transferase, catalase (CAT), and superoxide dismutase (SOD) activities were determined spectrophotometrically. eif4b, adsl, and shank3a expressions were determined by RT-PCR as autism-related genes. Although high-dose benzoic acid inhibited locomotor activity, benzoic acid at both doses ameliorated VPA-induced disruption in oxidant-antioxidant balance and inflammation in zebrafish embryos and was effective in improving the impaired expression of autism-related genes.
dc.identifier.citationCansız, D., Özokan, G., Bilginer, A., Işıkoğlu, S., Mızrak, Z., Ünal, İ. ... Emekli Alturfan, E. (2024). Effects of benzoic acid synthesized from cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos. Toxicology Mechanisms and Methods, 34(7), 833-843. http://dx.doi.org/10.1080/15376516.2024.2364899
dc.identifier.doi10.1080/15376516.2024.2364899
dc.identifier.endpage843
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue7
dc.identifier.pmid38888055
dc.identifier.scopus2-s2.0-85196296537
dc.identifier.scopusqualityQ2
dc.identifier.startpage833
dc.identifier.urihttp://dx.doi.org/10.1080/15376516.2024.2364899
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12849
dc.identifier.volume34
dc.identifier.wos001250722100001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCansız, Derya
dc.language.isoen
dc.relation.ispartofToxicology Mechanisms and Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBenozic Acid
dc.subjectCinnamomum Cassia
dc.subjectGreen Chemistry
dc.subjectValproic Acid
dc.subjectZebrafish Embryo
dc.titleEffects of benzoic acid synthesized from cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos
dc.typeArticle

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