Antimicrobial resistance patterns of uropathogens among children in Istanbul, Turkey

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dc.contributor.authorÖzahi İpek, İlke
dc.contributor.authorBozaykut, Abdulkadir
dc.contributor.authorÇaktır Arman, Didem
dc.contributor.authorSezer Gönül , Rabia
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:28Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:28Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractUrinary tract infections are a common cause of end-stage renal disease in Turkey. This prospective study investigated the antibiotic resistance patterns of uropathogens in order to recommend appropriate therapeutic protocols for children with urinary tract infections in Istanbul, Turkey. Between October 2007 and October 2008, children presenting with a first episode of urinary tract infection to a pediatric outpatient clinic were enrolled in the study. Urine samples were cultured, and antimicrobial susceptibility testing was performed. Children with proven urinary tract infections underwent imaging studies where available. A total of 126 children with a first episode of community-acquired urinary tract infection were enrolled in the study. The median age was 60.6 months; 84.1% of the children were female. Of the 126 urine samples, Escherichia coli was the leading uropathogen (81.7%), followed by Proteus spp (7.1%), Klebsiella spp (4.0%), Enterococcus spp (3.2%), Enterobacter spp (2.4%), and Pseudomonas spp (1.6%). Among the isolated uropathogens, resistance to ampicillin (85.0%), amoxicillin-clavulanate (73.8%), cefazolin (37.3%) and trimethoprim-sulfamethoxazole (42.9%) was remarkable. A large number of Enterococcus species were resistant to all antimicrobial agents except vancomycin. A country-based evaluation of antibiotic susceptibility is needed to modify antibiotic treatment. Resistance to antimicrobial agents commonly used to treat urinary tract infections (nitrofurantoin, cefixime) is less a problem than resistance to other antimicrobials (aminopenicillins, cephalosporins, trimethoprim-sulfamethoxazole) frequently prescribed for other indications.
dc.identifier.citationÖzahi İpek, İ., Bozaykut, A., Çaktır Arman, D. ve Sezer Gönül, R. (2011). Antimicrobial resistance patterns of uropathogens among children in Istanbul, Turkey. Southeast Asian Journal of Tropical Medicine and Public Health, 42(2), 355-362.
dc.identifier.endpage362
dc.identifier.issn0125-1562
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage355
dc.identifier.urihttps://hdl.handle.net/20.500.12511/792
dc.identifier.volume42
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofSoutheast Asian Journal of Tropical Medicine and Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibiotic Resistance
dc.subjectChildren
dc.subjectTurkey
dc.subjectUropathogens
dc.titleAntimicrobial resistance patterns of uropathogens among children in Istanbul, Turkey
dc.typeArticle

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