A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients

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dc.authorid0000-0002-2306-5937
dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-5118-4776
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorSütçübaşı, Bernis
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2023-09-26T06:49:24Z
dc.date.available2023-09-26T06:49:24Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIn Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in the pulvinar's subdivisions and total pulvinar voxel-based morphometry (VBM) changes in individuals with AD and healthy controls. A seed-based functional connectivity analysis was applied to the anterior, inferior, lateral, and medial pulvinar in each hemisphere. Furthermore, VBM analysis was carried out to compare gray matter (GM) volume differences in the pulvinar and thalamus between the two groups. Connectivity analysis revealed that the pulvinar subdivisions had decreased connectivity in individuals with AD. In addition, the pulvinar and thalamus in each hemisphere were significantly smaller in the AD group. The pulvinar may have a role in AD-related cognitive impairments and the intrinsic connectivity network changes and GM loss in pulvinar subdivisions suggest the cognitive deterioration occurring in those with AD. HighlightsThe pulvinar may play a role in pathophysiology of cognitive impairments in those with Alzheimer's disease (AD).Decreased structural volume and functional connectivity were found in patients with AD.The inferior pulvinar is functionally the most affected subdivision by AD compared to the others.
dc.description.sponsorshipIstanbul Medipol Universityen_US
dc.identifier.citationVelioğlu, H. A., Ayyıldız, B., Ayyıldız, S., Sütçübaşı, B., Hanoğlu, L., Bayraktaroğlu, Z. ... Yuluğ, B. (2023). A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients. Alzheimer's and Dementia, 19(7), 2774-2789. https://doi.org/10.1002/alz.12850
dc.identifier.doi10.1002/alz.12850
dc.identifier.endpage2789
dc.identifier.issn1552-5260
dc.identifier.issn1552-5279
dc.identifier.issue7
dc.identifier.pmid36576157
dc.identifier.scopus2-s2.0-85145302962
dc.identifier.scopusqualityQ1
dc.identifier.startpage2774
dc.identifier.urihttps://doi.org/10.1002/alz.12850
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11496
dc.identifier.volume19
dc.identifier.wos000904940000001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVelioğlu, Halil Aziz
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofAlzheimer's and Dementiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlzheimer’s Disease
dc.subjectCognitive Impairment
dc.subjectFunctional Magnetic Resonance Imaging
dc.subjectPulvinar
dc.subjectThalamus
dc.subjectVoxel-Basedmorphometry
dc.titleA structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
dc.typeArticle

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