Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions

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dc.authorid0000-0002-8440-367X
dc.contributor.authorBayram, Merve
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorReis, Maria
dc.contributor.authorTrombetta, Vanessa
dc.contributor.authorRuff, Timothy
dc.contributor.authorSencak, Regina
dc.contributor.authorHummel, Michael
dc.contributor.authorDizak, Piper
dc.contributor.authorWasham, Kelly
dc.contributor.authorRomanos, Helena
dc.contributor.authorLips, Andrea
dc.contributor.authorAlves, Gutemberg
dc.contributor.authorCosta, Marcelo
dc.contributor.authorGranjeiro, Jose
dc.contributor.authorAntunes, Leonardo
dc.contributor.authorKuechler, Erika
dc.contributor.authorSeymen, Figen
dc.contributor.authorVieira, Alexandre
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:38Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:38Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.descriptionWOS: 000361490800004
dc.descriptionPubMed ID: 26283008
dc.description.abstractClinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of the two dentitions are different. The purpose of this study was to test the hypothesis that genetic associations with an artificial caries model will not be the same between primary and permanent dentitions. Enamel samples from primary and permanent teeth were tested for microhardness at baseline, after carious lesion creation, and after fluoride application to verify association with genetic variants of selected genes. Associations were found between genetic variants of ameloblastin, amelogenin, enamelin, tuftelin, tuftelin interactive protein 11, and matrix metallopeptidase 20 and enamel from permanent teeth but not with enamel from primary teeth. In conclusion, our data continue to support that genetic variation may impact enamel development and consequently individual caries susceptibility. These effects may be distinct between primary and permanent dentitions.
dc.description.sponsorshipNIH [R01-DE18914]en_US
dc.description.sponsorshipThis study was supported by NIH Grant R01-DE18914. This paper was based, in part, on a thesis submitted to the graduate faculty, Istanbul University, in partial fulfillment of the requirements for a doctorate degree (M.B.).en_US
dc.identifier.citationBayram, M., Deeley, K., Reis, M., Trombetta, V., Ruff, T., Sencak, R. ... Vieira, A. (2015). Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions. European Journal of Oral Sciences, 123(5), 327-334. https://dx.doi.org/10.1111/eos.12204
dc.identifier.doi10.1111/eos.12204
dc.identifier.endpage334
dc.identifier.issn0909-8836
dc.identifier.issn1600-0722
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage327
dc.identifier.urihttps://dx.doi.org/10.1111/eos.12204
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2434
dc.identifier.volume123
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEuropean Journal of Oral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDental Caries
dc.subjectDentition
dc.subjectEnamel Microhardness
dc.subjectPermanent
dc.subjectPrimary
dc.titleGenetic influences on dental enamel that impact caries differ between the primary and permanent dentitions
dc.typeArticle

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