Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation

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dc.authorid0000-0003-0804-1475
dc.contributor.authorDandin, Esra
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÜnal, İsmail
dc.contributor.authorAteş Kalkan, Perihan Seda
dc.contributor.authorCansız, Derya
dc.contributor.authorBeler, Merih
dc.contributor.authorAk, Esin
dc.contributor.authorAlturfan, A. Ata
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2022-03-10T07:58:38Z
dc.date.available2022-03-10T07:58:38Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have been increasingly consumed. Stevia is a sweet natural glycoside and a calorie-free sweetner extracted from the leaves of Stevia rebaudiana Bertoni and used as a substitute for artificial sweetners. This study evaluates the effects of stevioside on glucose tolerance, epigenetic and metabolic regulators of insulin resistance, oxidant-antioxidant status and tissue histology in a diet-induced obese (DIO) zebrafish model. After 15 days of overfeeding body weight, and fasting blood glucose, lipid peroxidation and nitric oxide levels and the expressions of fbf21, lepa, ll21, tnf alpha were elevated, where as there was impaired glucose tolerance and lower superoxide dismutase and glutathione S-transferase activities, dnmt3a expression which is an epigenetic tool of insulin resistance. Beneficial effects of stevioside were observed on glucose tolerance, oxidative stress and inflammatory mediators linking obesity to insulin resistance and its epigenetic regulation, in DIO model.
dc.description.sponsorshipMarmara Universityen_US
dc.identifier.citationDandin, E., Üstündağ, Ü. V., Ünal, İ., Ateş Kalkan, P. S., Cansız, D. ve Beler, M. (2022). Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation. Obesity Research & Clinical Practice, 16(1), 23-29. https://doi.org/10.1016/j.orcp.2022.01.002
dc.identifier.doi10.1016/j.orcp.2022.01.002
dc.identifier.endpage29
dc.identifier.issn1871-403X
dc.identifier.issn1878-0318
dc.identifier.issue1
dc.identifier.pmid35031270
dc.identifier.scopus2-s2.0-85122614318
dc.identifier.scopusqualityQ2
dc.identifier.startpage23
dc.identifier.urihttps://doi.org/10.1016/j.orcp.2022.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9110
dc.identifier.volume16
dc.identifier.wos000755773400004en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜstündağ, Ünsal Veli
dc.institutionauthorCansız, Derya
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofObesity Research & Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDiet-Induced Obesity
dc.subjectGlucose Intolerance
dc.subjectOxidative Stress
dc.subjectStevioside
dc.subjectZebrafish
dc.titleStevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
dc.typeArticle

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