Unveiling the challenges of UTUC biopsies and cytology: insights from a global real-world practice study

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dc.authorid0000-0002-6308-1763
dc.authorid0000-0003-0906-4417
dc.contributor.authorBaard, Joyce
dc.contributor.authorCormio, Luigi
dc.contributor.authorDasgupta, Ranan
dc.contributor.authorMaruzzi, Daniele
dc.contributor.authorRais-Bahrami, Soroush
dc.contributor.authorSerrano, Alvaro
dc.contributor.authorGeavlete, Bogdan
dc.contributor.authorGiannakopoulos, Stilianos
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.date.accessioned2024-04-03T09:22:28Z
dc.date.available2024-04-03T09:22:28Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: Diagnostic ureteroscopy (dURS) is optional in the assessment of patients with upper tract urothelial carcinoma (UTUC) and provides the possibility of obtaining histology. Methods: To evaluate endoscopic biopsy techniques and outcomes, we assessed data from patients from the CROES-UTUC registry. The registry includes multicenter prospective collected data on diagnosis and management of patients suspected having UTUC. Results: We assessed 2380 patients from 101 centers. dURS with biopsy was performed in 31.6% of patients. The quality of samples was sufficient for diagnosis in 83.5% of cases. There was no significant association between biopsy techniques and quality (p = 0.458). High-grade biopsy accurately predicted high-grade disease in 95.7% and high-risk stage disease in 86%. In ureteroscopic low-grade tumours, the prediction of subsequent low-grade disease was 66.9% and low-risk stage Ta-disease 35.8%. Ureteroscopic staging correctly predicted non-invasive Ta-disease and ? T1 disease in 48.9% and 47.9% of patients, respectively. Cytology outcomes did not provide additional value in predicting tumour grade. Conclusion: Biopsy results adequately predict high-grade and high-risk disease, but approximately one-third of patients are under-staged. Two-thirds of patients with low-grade URS-biopsy have high-risk stage disease, highlighting the need for improved diagnostics to better assess patient risk and guide treatment decisions. Clinical trial registration: The study was registered at ClinicalTrials.gov (ClinicalTrials.gov NCT02281188; https://clinicaltrials.gov/ct2/show/NCT02281188).
dc.identifier.citationBaard, J., Cormio, L., Dasgupta, R., Maruzzi, D., Rais-Bahrami, S., Serrano, A. ... del Pilar Laguna Pes, M. (2024). Unveiling the challenges of UTUC biopsies and cytology: insights from a global real-world practice study. World Journal of Urology, 42(1). https://dx.doi.org/10.1007/s00345-024-04866-w
dc.identifier.doi10.1007/s00345-024-04866-w
dc.identifier.issn0724-4983
dc.identifier.issue1
dc.identifier.pmid38507109
dc.identifier.scopus2-s2.0-85188256598
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-024-04866-w
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12413
dc.identifier.volume42
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiopsy
dc.subjectCytology
dc.subjectKSS
dc.subjectUpper tract urothelial cancer
dc.subjectUreteroscopy
dc.titleUnveiling the challenges of UTUC biopsies and cytology: insights from a global real-world practice study
dc.typeArticle

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