Does the vitamin C level affect postoperative analgesia in patients who undergo orthognathic surgery?

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dc.authorid0000-0001-5121-9158
dc.authorid0000-0002-3245-6614
dc.authorid0000-0003-1077-7342
dc.contributor.authorSüzen, Muazzez
dc.contributor.authorZengin, Mustafa
dc.contributor.authorÇiftçi, Bahadır
dc.contributor.authorUçkan, Sina
dc.date.accessioned2023-02-16T06:00:11Z
dc.date.available2023-02-16T06:00:11Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractVitamin C has a critical role in pain management because of its antioxidative, neuroprotective, and anti-nociceptive properties. Oxidative stress caused by surgery increases the requirement for vitamin C. The aim of this study was to evaluate the change in vitamin C level and its effect on postoperative pain in patients undergoing orthognathic surgery. Thirty patients were included in the study. The relationships between the postoperative plasma vitamin C level, duration of surgery, postoperative analgesic consumption, and pain scores (visual analogue scale) were analysed. The difference between the mean pre-and postoperative vitamin C levels was found to be statistically significant (7.5 +/- 2.9 mg/l vs 4.9 +/- 2.3 mg/l, respectively; P = 0.001). There was no significant relationship between the duration of surgery and the vitamin C level decrease (P > 0.05). There was an inverse correlation between the postoperative vitamin C level and the amount of analgesic requested via patient-controlled analgesia (r = -0.699, P < 0.001). The findings suggest that, in patients who undergo orthognathic surgery, plasma vitamin C levels decrease significantly (34.6%), and an increase in the duration of surgery is not associated with any decrease in the vitamin C levels. A low postoperative plasma vitamin C level was found to be associated with greater postoperative analgesic consumption. In patients with preoperative plasma vitamin C levels <= 42 mu mol/l, perioperative vitamin C administration may be considered for postoperative pain management.
dc.identifier.citationSüzen, M., Zengin, M., Çiftçi, B. ve Uçkan, S. (2023). Does the vitamin C level affect postoperative analgesia in patients who undergo orthognathic surgery? International Journal of Oral and Maxillofacial Surgery, 52(2), 205-210. https://doi.org/10.1016/j.ijom.2022.06.005
dc.identifier.doi10.1016/j.ijom.2022.06.005
dc.identifier.endpage210
dc.identifier.issn0901-5027
dc.identifier.issn1399-0020
dc.identifier.issue2
dc.identifier.pmid35791994
dc.identifier.scopus2-s2.0-85133376366
dc.identifier.scopusqualityQ1
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1016/j.ijom.2022.06.005
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10454
dc.identifier.volume52
dc.identifier.wos000918335600001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSüzen, Muazzez
dc.institutionauthorZengin, Mustafa
dc.institutionauthorÇiftçi, Bahadır
dc.institutionauthorUçkan, Sina
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOrthognathic Surgery
dc.subjectVitamin C
dc.subjectOxidative Stress
dc.subjectPostoperative Pain
dc.subjectAnalgesia
dc.titleDoes the vitamin C level affect postoperative analgesia in patients who undergo orthognathic surgery?
dc.typeArticle

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