Topical single-dose vascular endothelial growth factor has no effect on soft tissue healing

Basit Öğe Kaydı
dc.authorid0000-0002-0060-2859
dc.contributor.authorBölükbaşı, Nilüfer
dc.contributor.authorBalcıoğlu, Hüseyin Avni
dc.contributor.authorÖzkan, Birkan T.
dc.contributor.authorSoluk Tekkesin, Merva
dc.contributor.authorÜstek, Duran
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:12Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:12Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractBackground: Vascular endothelial growth factor (VEGF) production in dermal wounds has been evaluated for evidence that it plays a probable role in wound healing. Events such as increased vascular permeability and concentration of infl ammatory cells on the site of injury, produced by VEGF, were linked to tissue repair. Aim: The present study aimed to evaluate the effects of single-dose topical administration of VEGF on wound healing. Materials and Methods: A total of 30 male Wistar albino rats weighing 250-280 g were used in this study. In addition, 2-cm-long skin incisions were created over bilaterally exposed skin of the tibia region in each rat. VEGF plasmid 2 µg was administered locally into the right side wound bed of each animal. No other procedure besides skin closure was administered on the left side. To determine histologic assessments, skin samples were obtained from six anesthetized rats at each interval (4, 8, 12, 16 and 30 days) through excisional biopsy. The tissues were fi xed in 10% neutral-buffered formalin for 1 week and then embedded in paraffi n wax. Transverse sections of the embedded tissue 5-7 µm thick were stained with hematoxylin and eosin (H and E). Results: There was no signifi cant difference regarding necrosis, epithelialization, infl ammation, fi broblast activity, ulcerative formation, or hemorrhage between experimental and control groups. No statistically signifi cant difference was found between the groups regarding granulation tissue formation and epidermal thickness. Conclusion: The administration method and dosage of VEGF is a major factor in terms of its effectiveness. The results of the present study did not evaluate the effectiveness of single-dose 2 µg topical administration of VEGF; however, various doses of VEGF plasmid should be tested in future studies in order to provide benefi cial effects from topical administration of VEGF.
dc.identifier.citationBölükbaşı, N., Balcıoğlu, H. A., Özkan, B. T., Soluk Tekkesin, M. ve Üstek, D. (2014). Topical single-dose vascular endothelial growth factor has no effect on soft tissue healing. North American Journal of Medical Sciences, 6(10), 505-509. https://dx.doi.org/10.4103/1947-2714.143281
dc.identifier.doi10.4103/1947-2714.143281
dc.identifier.endpage509
dc.identifier.issn2250-1541
dc.identifier.issue10
dc.identifier.scopusqualityQ2
dc.identifier.startpage505
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1351
dc.identifier.urihttps://dx.doi.org/10.4103/1947-2714.143281
dc.identifier.volume6
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNorth American Journal of Medical Sciences
dc.relation.ispartofNorth American Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAngiogenesis
dc.subjectVascular Endothelial Growth Factor
dc.subjectVascular Permeability
dc.subjectWound Healing
dc.titleTopical single-dose vascular endothelial growth factor has no effect on soft tissue healing
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
ustek-duran(2014).pdf
Boyut:
794.02 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Diş Hekimliği Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu