Impact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity

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dc.contributor.authorErşahin, Aynur
dc.contributor.authorÇelik, Önder
dc.contributor.authorAcet, Mustafa
dc.contributor.authorErşahin, Süphan
dc.contributor.authorAcet, Tuba
dc.contributor.authorKara Bozkurt, Duygu
dc.contributor.authorYavuz, Yasemin
dc.contributor.authorİlhan, Selçuk
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:51Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000400087600017
dc.descriptionPubMed ID: 27678098
dc.description.abstractThe aim of this study was to determine whether endometrioma resection alters most commonly defined endometrial metabolites, lactate (Lac), N-acetylaspartate (NAA), creatine 1 (Cr1), creatine 2 (Cr2), and choline (Cho) during the window of implantation. Twenty patients with uni- or bilateral endometrioma and 7 patients having nonendometriotic benign ovarian cyst were included. Midluteal phase magnetic resonance spectroscopy analysis of eutopic endometrium was performed before surgery. Second spectrum of endometrium was obtained 3 to 5 months after laparoscopic endometrioma resection. Pre- and postoperative endometrial peaks of Lac, NAA, Cr, and Cho were measured in units and denominated in parts per million (ppm). Compared to preoperative peak values, significantly decreased NAA, Lac, and Cr1 signals were noted in patients undergoing endometrioma surgery. Nearly 5-fold decline in the NAA signal occurred after endometrioma surgery (1.94 +/- 3.24 vs 0.37 +/- 0.55). Likewise, 2.5-fold decline in Lac signals was noted after endometrioma resection (2.81 +/- 2.64 vs 1.06 +/- 1.88). Both uni- and bilateral endometrioma affected endometrium signals the same. The peak intensity of Cho, Cr1, Cr2, NAA, and Lac did not alter significantly after nonendometriotic cyst surgery. Endometrioma surgery straightens endometrial NAA, Lac, and Cr1 peaks, suggesting improvement in endometrial receptivity.
dc.identifier.citationErşahin, A., Çelik, Ö., Acet, M., Erşahin, S., Acet, T., Kara Bozkurt, D. ... İlhan, S. (2017). Impact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity. Reproductive Sciences, 24(5), 790-795. https://dx.doi.org/10.1177/1933719116670039
dc.identifier.doi10.1177/1933719116670039
dc.identifier.endpage795
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage790
dc.identifier.urihttps://dx.doi.org/10.1177/1933719116670039
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3749
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSpectroscopy
dc.subjectEndometrioma
dc.subjectEutopic Endometrium
dc.subjectLaparoscopy
dc.titleImpact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity
dc.typeArticle

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