A randomized, placebo-controlled, double-blind study that evaluates efficacy of intravenous ibuprofen and acetaminophen for postoperative pain treatment following laparoscopic cholecystectomy surgery

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dc.authorid0000-0002-5580-5960
dc.authorid0000-0002-3245-6614
dc.authorid0000-0003-0428-2511
dc.contributor.authorEkinci, Mürsel
dc.contributor.authorÇiftçi, Bahadır
dc.contributor.authorÇelik, Erkan Cem
dc.contributor.authorKöse, Emine Arzu
dc.contributor.authorKarakaya, Muhammet Ahmet
dc.contributor.authorÖzdenkaya, Yaşar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:38Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:38Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: Ibuprofen is a NSAID that has anti-inflammatory, antipyretic, and analgesic effects. The oral form of the drug has been used safely for a long time and is one of the most preferred NSAIDs. It has been shown that ibuprofen is effective in the treatment of postoperative pain; however, there have not been sufficient studies on ibuprofen. We evaluated and compared the influence of IV forms of ibuprofen and acetaminophen on pain management and opioid consumption on patients undergoing laparoscopic cholecystectomy surgery. Methods: Patients were stratified into three groups. Group I (group ibuprofen, n = 30) was administered 800 mg of IV ibuprofen; group A (group acetaminophen, n = 30) was administered 1000 mg of IV acetaminophen; and group C (control group, n = 30) was given 100 ml of saline solution. We evaluated opioid consumption and VAS scores postoperatively. Results: Pain scores in group I and group A at all time periods were lower than those in group C (p < 0.05). Group I had significantly lower VAS scores than those in group A at all time periods postoperatively (p < 0.05). Those in group C had significantly higher opioid consumption than the other groups (p < 0.05). Opioid consumption in group I at all time periods postoperatively was significantly lower than those in group A (p < 0.05). Group I had statistically lower rescue medication than the other groups at all time periods. Conclusion: Our study suggested that IV ibuprofen resulted in lower pain scores and reduced opioid use compared with acetaminophen postoperatively in the first 24 h in patients undergoing laparoscopic cholecystectomy surgery.
dc.identifier.citationEkinci, M., Çiftçi, B., Çelik, E. C., Köse, E. A., Karakaya, M. A. ve Özdenkaya, Y. (2020). A randomized, placebo-controlled, double-blind study that evaluates efficacy of intravenous ibuprofen and acetaminophen for postoperative pain treatment following laparoscopic cholecystectomy surgery. Journal of Gastrointestinal Surgery, 24(4), 780-785. https://dx.doi.org/10.1007/s11605-019-04220-1
dc.identifier.doi10.1007/s11605-019-04220-1
dc.identifier.endpage785
dc.identifier.issn1091-255X
dc.identifier.issn1873-4626
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage780
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1444
dc.identifier.urihttps://dx.doi.org/10.1007/s11605-019-04220-1
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer New York LLC
dc.relation.ispartofJournal of Gastrointestinal Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnalgesia
dc.subjectIbuprofen
dc.subjectLaparoscopic Cholecystectomy
dc.titleA randomized, placebo-controlled, double-blind study that evaluates efficacy of intravenous ibuprofen and acetaminophen for postoperative pain treatment following laparoscopic cholecystectomy surgery
dc.typeArticle

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