A retrospective analysis of anaerobic bacteria isolated in 236 cases of pleural empyema and their prevalance of antimicrobial resistance in Turkey

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dc.authorid0000-0003-0394-8772
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorGemicioğlu, Bilun
dc.contributor.authorSarıbaş, Suat
dc.contributor.authorHalis, Ayşe Nigar
dc.contributor.authorTaner, Zeynep
dc.contributor.authorMamal Torun, Müzeyyen
dc.contributor.authorKaratoka, Belma
dc.contributor.authorAşık Çağlı, Linda
dc.contributor.authorGüven, Özlem
dc.contributor.authorDemiryas, Süleyman
dc.contributor.authorKocazeybek, Bekir Sami
dc.contributor.authorBahar Tokman, Hrisi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:18Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:18Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000442664700022
dc.descriptionPubMed ID: 30146848
dc.description.abstractBackground: Parapneumonic effusions usually occur secondary to an infection and produce pus (empyema) that accumulates in the pleural space. We aimed to evaluate the prevalence of anerobes in patients with empyema and to assess their resistance patterns for seven antimicrobials. Methods: Pleural fluid specimens from 236 patients were inoculated on Schaedler agar. Anaerobic bacteria were identified via API 20 A. Susceptibility testing for penicillin, ampicillin + sulbactam, amoxicillin + clavulanate, cefoxitin, clindamycin, metronidazole, and imipenem were performed with the E-test. Results: There were 118 anaerobic bacterial strains detected in 66 (27.9%) of the 236 specimens. Gram-positive anaerobic cocci were detected in 54.23% and the predominant cocci were 41 Peptostreptococcus spp, (34.75%) followed by 17 P. acnes (14.41%) and 6 C. tertium (5.08%). The Gram-negative anaerobes were B. fragilis (28, 23.73%), P. melaninogenica (8, 6.78%), P. intermedia (4, 3.39%), F. nucleatum (6, 5.08%), F mortiferum (5, 4.24%), and P. asaccharolytica (3, 2.54%). All anaerobic strains were susceptible to ampicillin + sulbactam, amoxicillin + clavulanate, and imipenem. The highest MIC was found to be> 256 mu g/mL for penicillin in B. fragilis strains, 128 mu g/mL for cefoxitin in P. melaninogenica strains, 32 mu g/mL for clindamycin and 64 mu g/mL for metronidazole in P. acnes strains. Clindamycin resistance was detected in 46.6% B. fragilis, and 17.6% for P. acnes. Thirty-eight (32.2%) strains produced beta-lactamase. Conclusions: The use of antimicrobial agents for thoracic empyema should be based on the isolated pathogens and their resistance profiles. Clinicians should be aware of the wide diversity of anaerobic genera and species in cases of pleural empyema.
dc.description.sponsorshipIstanbul University Research Found [BYP-900/19.012.006]en_US
dc.description.sponsorshipThis study was supported by Istanbul University Research Found. Project no BYP-900/19.012.006.en_US
dc.identifier.citationDemirci, M., Gemicioğlu, B., Sarıbaş, S., Halis, A., Taner, Z., Mamal Torun, M. ... Bahar Tokman, H. (2018). A retrospective analysis of anaerobic bacteria isolated in 236 cases of pleural empyema and their prevalance of antimicrobial resistance in Turkey. Clinical Laboratory, 64(7-8), 1269-1277. https://dx.doi.org/10.7754/Clin.Lab.2018.180317
dc.identifier.doi10.7754/Clin.Lab.2018.180317
dc.identifier.endpage1277
dc.identifier.issn1433-6510
dc.identifier.issue45511
dc.identifier.scopusqualityQ3
dc.identifier.startpage1269
dc.identifier.urihttps://dx.doi.org/10.7754/Clin.Lab.2018.180317
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2191
dc.identifier.volume64
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinical Laboratory Publ
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnaerobic Bacteria
dc.subjectPleural Empyema
dc.subjectAntimicrobial Resistance
dc.titleA retrospective analysis of anaerobic bacteria isolated in 236 cases of pleural empyema and their prevalance of antimicrobial resistance in Turkey
dc.typeArticle

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