Clinical outcomes of uterine carcinosarcoma results of 94 patients

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dc.authorid0000-0001-6136-5597
dc.contributor.authorGökçe, Zeynep Kestel
dc.contributor.authorTuran, Taner
dc.contributor.authorKaralok, Alper
dc.contributor.authorTasçı, Tolga
dc.contributor.authorÜreyen, Işın
dc.contributor.authorÖzkaya, Enis
dc.contributor.authorKöse, Mehmet Faruk
dc.contributor.authorTulunay, Gökhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:41Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000348831000015
dc.descriptionPubMed ID: 25611900
dc.description.abstractObjective: We aimed to determine the clinicopathologic features and identify prognostic factors of patients with uterine carcinosarcoma. Materials and Methods: A total of 94 patients with uterine carcinosarcoma who were diagnosed between January 1993 and October 2013 were included. Staging surgery consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy, peritoneal cytology, and omentectomy. Staging is undertaken according to the 2009 International Federation of Gynecology and Obstetrics staging system. Kaplan-Meier survival analysis was used to determine the effects of variables on disease-free survival (DFS) and overall survival (OS). Results: Seventy-nine patients underwent staging surgery and none of them had residual tumor after surgery. Three-year DFS and 3-year OS were 42.7% and 59.2%, respectively. In the univariate analysis, stage, presence of para-aortic metastatic lymph nodes, uterine serosal spread, positive peritoneal cytology, and extrapelvic metastases were associated with 3-year DFS and stage, presence of para-aortic metastatic lymph nodes, uterine serosal spread, positive peritoneal cytology, adnexal involvement, and extrapelvic metastases were associated with 3-year OS. Seventy-four patients received adjuvant therapy. Adjuvant therapy did not reduce recurrence or improve survival. Any of the chemotherapy regimens was not superior to the others. In the multivariate analysis, only age was an independent prognostic factor for 3-year DFS and no parameter was statistically significant for 3-year OS. Conclusions: Age was an independent prognostic factor for 3-year DFS. Older age was associated with poor survival. Extrauterine spread was associated with survival. The aims of surgery should be both staging and providing tumoral debulking. Prospective randomized trials are needed to better define the necessity and modality of the administered adjuvant therapy.
dc.identifier.citationGökçe, Z. K., Turan, T., Karalok, A., Tasçı, T., Üreyen, I., Özkaya, E. ... Tulunay, G. (2015). Clinical outcomes of uterine carcinosarcoma results of 94 patients. İnternational Journal of Gynecological Cancer, 25(2), 279-287. https://dx.doi.org/10.1097/IGC.0000000000000347
dc.identifier.doi10.1097/IGC.0000000000000347
dc.identifier.endpage287
dc.identifier.issn1048-891X
dc.identifier.issn1525-1438
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage279
dc.identifier.urihttps://dx.doi.org/10.1097/IGC.0000000000000347
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2786
dc.identifier.volume25
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofİnternational Journal of Gynecological Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCarcinosarcoma
dc.subjectMalignant Mixed Mullerian Tumor
dc.subjectUterine Neoplasm
dc.subjectAdjuvant Therapy
dc.subjectSurvival
dc.titleClinical outcomes of uterine carcinosarcoma results of 94 patients
dc.typeArticle

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