Effects of putrescine, spermidine and spermine on growth and serum lipid levels in sprague-dawley rat offspring

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dc.authorid0000-0002-5625-3387
dc.authorid0000-0003-1420-0989
dc.contributor.authorMert Biberoğlu, Fatma
dc.contributor.authorBüyükuslu, Nihal
dc.date.accessioned2022-05-06T12:01:02Z
dc.date.available2022-05-06T12:01:02Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Beslenme ve Diyetetik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractPolyamines are short-chain, basic biogenic amines that are essential for cell growth and reproduction. This study was conducted to examine the effects of maternal polyamine intake on growth and serum lipid levels in first generation rat offspring. Female Sprague-Dawley rats (n=35) of 8 weeks old were used in the study. Rats were divided into five groups according to the polyamine they are fed as putrescine, spermidine, spermine, putrescine-spermidine-spermine, and control group. Before pregnancy, during pregnancy and lactation polyamines were administered to rats by oral gavage. After the offsprings were born, weights were measured every two days. Blood samples were taken when they were one month old and serum lipid analyzes were performed. When the groups were compared with the control group, it was shown that spermidine and spermine significantly increased the total cholesterol level, spermidine and putrescine-spermidine-spermine significantly decreased the triglyceride level and significantly increased the HDL level of the spermine. When birth weight averages and final weight averages were compared, it was seen that the group given putrescine-spermidine-spermine had the highest value. In conclusion, this study shows the effects of maternal polyamine intake on growth, total cholesterol, HDL, LDL and triglyceride levels of rat offsprings.
dc.identifier.citationMert Biberoğlu, F. ve Büyükuslu, N. (2022). Effects of putrescine, spermidine and spermine on growth and serum lipid levels in sprague-dawley rat offspring. Acta Pharmaceutica Sciencia, 60(1), 101-116. https://doi.org/10.23893/1307-2080.APS.6007
dc.identifier.doi10.23893/1307-2080.APS.6007
dc.identifier.endpage116
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85128743085
dc.identifier.scopusqualityQ3
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.23893/1307-2080.APS.6007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9413
dc.identifier.volume60
dc.indekslendigikaynakScopus
dc.institutionauthorMert Biberoğlu, Fatma
dc.institutionauthorBüyükuslu, Nihal
dc.language.isoen
dc.publisherIstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLipid Profile
dc.subjectPolyamine
dc.subjectPutrescine
dc.subjectSpermidine
dc.subjectSpermine
dc.titleEffects of putrescine, spermidine and spermine on growth and serum lipid levels in sprague-dawley rat offspring
dc.typeArticle

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