Evaluating bioactivity and bioaccessibility properties of the propolis extract prepared with L-lactic acid: An alternative solvent to ethanol for propolis extraction

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dc.authorid0000-0003-4568-4234
dc.authorid0000-0002-8164-358X
dc.contributor.authorAtayoğlu, Ali Timuçin
dc.contributor.authorSözeri Atik, Didem
dc.contributor.authorBölük, Esra
dc.contributor.authorGürbüz, Başak
dc.contributor.authorCeylan, Fatma Duygu
dc.contributor.authorÇapanoğlu, Esra
dc.contributor.authorAtayolu, Rümeysa
dc.contributor.authorParadkar, Anant
dc.contributor.authorFearnley, James
dc.contributor.authorPalabıyık, İbrahim
dc.date.accessioned2023-06-09T13:12:31Z
dc.date.available2023-06-09T13:12:31Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Geleneksel ve Tamamlayıcı Tıp (İntegratif Tıp) Ana Bilim Dalı
dc.description.abstractEthanol readily solubilizes the active components of propolis. Due to certain disadvantages of ethanolic extracts, developing new non-ethanolic extraction methods is highly desirable. This study aimed to determine the content of phenolic compounds and antioxidant activity of propolis by using lactic acid extraction compared to ethanol. Various concentrations of ethanol and lactic acid were utilized to produce extracts, and an in vitro digestion procedure was applied to the extracts to compare the bioaccessibility of phenolic compounds by using LC-MS/MS in extracts and HPLC-DAD in digested samples. The compounds detected in the lactic acid-based propolis solution had similar values to those in the ethanol solution at a propolis concentration of 10%. The propolis-lactic acid solution had a significantly higher antioxidant activity against DPPH radical than the one prepared with ethanol at the same concentration (p < 0.05). Chrysin and naringenin were found as the most abundant phenolic compounds in the initial samples during in vitro digestion experiments. Pinocembrin was the most bioaccessible component among the dialyzed IN fractions of ethanol and lactic acid-based solutions, whereas some compounds were not detected. The results suggest that lactic acid may be used as an alternative to ethanol for propolis extraction.
dc.description.sponsorshipUniversity of Californiaen_US
dc.identifier.citationAtayoğlu, A. T., Sözeri Atik, D., Bölük, E., Gürbüz, B., Ceylan, F. D., Çapanoğlu, E. ... Palabıyık, İ. (2023). Evaluating bioactivity and bioaccessibility properties of the propolis extract prepared with L-lactic acid: An alternative solvent to ethanol for propolis extraction. Food Bioscience, 53. https://doi.org/10.1016/j.fbio.2023.102756
dc.identifier.doi10.1016/j.fbio.2023.102756
dc.identifier.issn2212-4292
dc.identifier.scopus2-s2.0-85160066079
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2023.102756
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11061
dc.identifier.volume53
dc.identifier.wos001009576500001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAtayoğlu, Ali Timuçin
dc.institutionauthorAtayolu, Rümeysa
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofFood Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant
dc.subjectExtraction
dc.subjectLactic Acid
dc.subjectPhenolics
dc.subjectPropolis
dc.titleEvaluating bioactivity and bioaccessibility properties of the propolis extract prepared with L-lactic acid: An alternative solvent to ethanol for propolis extraction
dc.typeArticle

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