Tissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients

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dc.authorid0000-0002-4728-1079
dc.authorid0000-0003-0804-1475
dc.authorid0000-0002-8662-5284
dc.authorid0000-0002-7059-1884
dc.authorid0000-0002-5919-1986
dc.contributor.authorAlkan Bozkaya, Tijen
dc.contributor.authorAteş, Şanser
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorKeskin, İlknur
dc.contributor.authorYiğit, Pakize
dc.contributor.authorYiğitbaşı, Ahmet
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned2023-05-22T13:08:39Z
dc.date.available2023-05-22T13:08:39Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalı
dc.description.abstractBackgroundAtherosclerosis, which is one of the leading causes of death all over the world, can create major or minor thromboembolic complications with the exponentially increasing diabetic status. Despite all the studies, the mechanism by which endothelial damage in atherosclerosis is triggered in diabetic setting is still not fully understood. MethodsIn this study, tissue factor (TF), which is thought to act together in the formation of vasular endothelial growth factor (VEGF-A) and coagulopathy in diabetic atherosclerotic patients, may be an important indicator in this regard, a total of 100 cases who were undergone off-pump coronary artery bypass (OPCAB) which were at same risk group examined by dividing into diabetic status. Early postoperative process and biochemical parameters analyzed in terms of TF and VEGF-A levels measured before and after the operation. ResultsTF and VEGF-A expression of the T1DM group were statistically high compared to non-diabetics. Significantly longer hospital stays with changes in TF and VEGF-A were found in patients in the diabetic group compared to pre- and postoperatively, respectively; TF (95% CI: 0.879-0.992; p = 0.025), VEGF-A (95% CI: 0.964-0.991; p = 0.001) and hospital stay (95% CI: 1.96-7.49; p = 0.0001). Preoperatively measured carotid intima-media thickness (CT) was higher in diabetics and was significantly associated with atrial fibrillation (AF), (r = 0.873). Surgical team and protocols were same and OPCAB procedures were routinely applied to all patients in our clinic. No minor or major events were observed in any of the cases. ConclusionTF and VEGF-A values in patients with diabetic atherosclerosis may be important in the early detection of thromboembolic complications.
dc.identifier.citationAlkan Bozkaya, T., Ateş, Ş., Üstündağ, Ü. V., Çakıcı, Ç., Keskin, İ., Yiğit, P. ... Emekli, N. (2023). Tissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 17. https://doi.org/10.1177/11795484231167737
dc.identifier.doi10.1177/11795484231167737
dc.identifier.issn1179-5484
dc.identifier.pmid37113616
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1177/11795484231167737
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10948
dc.identifier.volume17
dc.identifier.wos000971247200001en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlkan Bozkaya, Tijen
dc.institutionauthorÜstündağ, Ünsal Veli
dc.institutionauthorÇakıcı, Çağrı
dc.institutionauthorKeskin, İlknur
dc.institutionauthorYiğit, Pakize
dc.institutionauthorYiğitbaşı, Ahmet
dc.institutionauthorEmekli, Nesrin
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofClinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAtherosclerosis
dc.subjectDiabetes
dc.subjectTissue Factor
dc.subjectVascular Endothelial Growth Factor
dc.subjectAtrial Fibrillation
dc.titleTissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients
dc.typeArticle

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