Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing

Basit Öğe Kaydı
dc.authorid0000-0002-7059-1884
dc.authorid0000-0001-7702-2441
dc.authorid0000-0003-2143-5268
dc.authorid0000-0001-7933-4262
dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-6895-8560
dc.authorid0000-0002-8084-7855
dc.contributor.authorKeskin, İlknur
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorAyla, Şule
dc.contributor.authorKolbaşı, Bircan
dc.contributor.authorSayın Şakul, Arzu Ayşe
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorGök, Özlem
dc.contributor.authorKöroğlu, Kutay M.
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:45Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:45Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractWe investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and limonene were applied topically to the wounds once daily, separately or together, for 10 days. Tissue sections from the wounds were evaluated for histopathology. The healing potential was assessed by comparison to an untreated control group and an olive oil treated sham group. We scored wound healing based on epidermal regeneration, granulation tissue thickness and angiogenesis. After day 6, wound contraction with limonene was significantly better than for the control group. Ten days after treatment, a significant increase was observed in wound contraction and re-epithelialization in both fenchone and limonene oil treated groups compared to the sham group. Groups treated with fenchone and with fenchone + limonene scored significantly higher than the control group, but the difference was not statistically significant compared to the olive oil treated group. Our findings support the beneficial effects of fenchone and limonene for augmenting wound healing. The anti-inflammatory and antimicrobial activities of fenchone and limonene oil increased collagen synthesis and decreased the number of inflammatory cells during wound healing and may be useful for treating skin wounds.
dc.identifier.citationKeskin, İ., Günal, M. Y., Ayla, Ş., Kolbaşı, B., Sayın Şakul, A. A. … Özbek, H. (2017). Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing. Biotechnic and Histochemistry, 92(4), 274-282. https://dx.doi.org/10.1080/10520295.2017.1306882
dc.identifier.doi10.1080/10520295.2017.1306882
dc.identifier.endpage282
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage274
dc.identifier.urihttps://hdl.handle.net/20.500.12511/932
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2017.1306882
dc.identifier.volume92
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEssential Oil
dc.subjectFenchone
dc.subjectFoeniculum Vulgare
dc.subjectLimonene
dc.subjectRats
dc.subjectWound Healing
dc.titleEffects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Keskin-Ilknur--2017.pdf
Boyut:
611.38 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu