Association between FVL G1691A, FII G20210A, and MTHFR C677T and A1298C polymorphisms and Turkish women with recurrent pregnancy loss

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dc.authorid0000-0002-1971-4092
dc.authorid0000-0001-9442-2690
dc.contributor.authorYengel, İrem
dc.contributor.authorYorulmaz, Tülay
dc.contributor.authorApi, Murat
dc.date.accessioned2020-12-21T08:06:11Z
dc.date.available2020-12-21T08:06:11Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractAim Recurrent pregnancy loss (RPL) poses a challenge in reproductive medicine because the etiology is often unknown. Here we investigated the frequency of mutations in the Factor V Leiden (FVL), prothrombin (FII), and methylene tetrahydrofolate reductase (MTHFR) genes in women with RPL and healthy women. Methods Blood samples were obtained from patients with ?2 consecutive pregnancy losses and no identifiable etiology before 12 weeks of pregnancy (n=145). The control group comprised 105 age-matched women with ?2 live births. Results The frequency of homozygotes for FVL 1691AA was 15 (10.3%) in patients and three (2.86%) in controls (p=0.073), while for FII 20210AA it was eight (5.5%) and one (0.9%), respectively (p=0.055). For two polymorphisms in MTHFR, genotype frequencies of 89 (61.4%) were found in patients and 55 (52.4%) in controls for 677TT (p=0.322), and 89 (61.4%) and 62 (59%) for 1298CC, respectively (p=0.810). Conclusion Despite a trend towards significance for FII G20210A, no significant differences in genotype frequencies of these polymorphisms between patients and controls was found. No evidence of the role of FVL G1691A, MTHFR C677T, and MTHFR A1298C in RPL in our Turkish cohort was found; however, further investigation of FII as a culprit gene in RPL is warranted.
dc.identifier.citationYengel, İ., Yorulmaz, T. ve Api, M. (2020). Association between FVL G1691A, FII G20210A, and MTHFR C677T and A1298C polymorphisms and Turkish women with recurrent pregnancy loss. Medicinski Glasnik, 17(1), 129-135. https://dx.doi.org/10.17392/1062-20
dc.identifier.doi10.17392/1062-20
dc.identifier.endpage135
dc.identifier.issn1840-0132
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage129
dc.identifier.urihttps://dx.doi.org/10.17392/1062-20
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6109
dc.identifier.volume17
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedical Association of Zenica-Doboj Canton
dc.relation.ispartofMedicinski Glasniken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGene Polymorphisms
dc.subjectHabitual Abortions
dc.subjectMTHFR A1298C
dc.subjectMTHFR C677T Polymorphisms
dc.subjectMethylenetetrahydrofolate Reductase
dc.subjectThrombophilia
dc.titleAssociation between FVL G1691A, FII G20210A, and MTHFR C677T and A1298C polymorphisms and Turkish women with recurrent pregnancy loss
dc.typeArticle

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