The impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study

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dc.authorid0000-0002-2035-9462
dc.contributor.authorÇelik, Serhat
dc.contributor.authorKaynar, Leylagül
dc.contributor.authorGüven, Zeynep Tuğba
dc.contributor.authorKeni Beğendi, Nermin
dc.contributor.authorDemir, Fatma
dc.contributor.authorKeklik, Muzaffer
dc.contributor.authorÜnal, Ali
dc.date.accessioned2024-01-15T08:55:26Z
dc.date.available2024-01-15T08:55:26Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Factors such as age, underlying hematological disease, chemotherapy and radiotherapy used, and bone marrow infiltration may cause mobilization failure. Several preclinical observed that diabetes mellitus (DM) leads to profound remodeling of the hematopoietic stem cell (HSC) niche, resulting in the impaired release of HSCs. We aim to examine the effect of DM on HSC mobilization and to investigate whether there is a relationship between complications developing in the DM process and drugs used to treat DM and mobilization failure. Methods: In Erciyes University Bone Marrow Transplantation Unit, 218 patients who underwent apheresis for stem cell mobilization between 2011 and 2021 were evaluated retrospectively. One hundred and nine patients had a diagnosis of DM, and 109 did not. Results: Mobilization failure developed in 17 (15.6 %) of the patients in the DM group, while it developed in 7 (6.4 %) patients in the non-DM group (p = 0.03). CD34+ stem cell count was 8.05 (1.3-30.2) x 106/kg in the DM group, while it was 8.2 (1.7-37.3) x 106/kg in the other group (p = 0.55). There was no statistically significant relationship between glucose and hemoglobin A1c levels and the amount of CD34+ cells (p = 0.83 and p = 0.14, respectively). Using sulfonylurea was the only independent predictor of mobilization failure (OR 5.75, 95 % CI: 1.38-24.05, p = 0.02). Conclusion: DM should be considered a risk factor for mobilization failure. Further research is needed fully to understand the mechanisms underlying the mobilization failure effects of sulfonylureas and to develop strategies to improve stem cell mobilization in diabetic patients.
dc.identifier.citationÇelik, S., Kaynar, L., Güven, Z. T., Keni Beğendi, N., Demir, F., Keklik, M. ... Ünal, A. (2023). The impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study. Transfusion and Apheresis Science, 62(6). https://dx.doi.org/10.1016/j.transci.2023.103838
dc.identifier.doi10.1016/j.transci.2023.103838
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue6
dc.identifier.pmid37925340
dc.identifier.scopus2-s2.0-85175823110
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1016/j.transci.2023.103838
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12138
dc.identifier.volume62
dc.identifier.wos001132099300001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaynar, Leylagül
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes Mellitus
dc.subjectHematopoietic Stem Cell
dc.subjectMobilization
dc.subjectSulfonylurea
dc.titleThe impact of diabetes mellitus on hematopoietic stem cell mobilization, a-single center cohort study
dc.typeArticle

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