Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis

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dc.authorid0000-0001-8945-2385
dc.contributor.authorİnanç Balkan, İlker
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorA?alar, Canan
dc.contributor.authorAkalın, Şerife
dc.contributor.authorAlıcı, Özlem
dc.contributor.authorAlp, Emine
dc.contributor.authorAltay, Fatma Aybala
dc.contributor.authorAltın, Nilgün
dc.contributor.authorArslan, Ferhat
dc.contributor.authorAslan, Turan
dc.contributor.authorBekiroğlu, Nural
dc.contributor.authorCesur, Salih
dc.contributor.authorDo?an Çelik, Aygül
dc.contributor.authorDo?an, Mustafa
dc.contributor.authorDurdu, Bülent
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorEngin, Aynur
dc.contributor.authorÖztürk Engin, Derya
dc.contributor.authorGönen, İbak
dc.contributor.authorGüçlü, Ertuğrul
dc.contributor.authorGüven, Tümer
dc.contributor.authorHatipo?lu, Çi?dem
dc.contributor.authorHoşo?lu, Salih
dc.contributor.authorKarahocagil, Mustafa Kasım
dc.contributor.authorUlu Kılıç, Ayşegül
dc.contributor.authorÖrmen, Bahar
dc.contributor.authorÖzdemir, Davut
dc.contributor.authorÖzer, Serdar
dc.contributor.authorÖztoprak, Nefise
dc.contributor.authorSezak, Nur Banu
dc.contributor.authorTurhan, Vedat
dc.contributor.authorTürker, Nesrin
dc.contributor.authorYılmaz, Hava
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:24Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000349144300018
dc.descriptionPubMed ID: 25821319
dc.description.abstractObjectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.
dc.identifier.citationİnanç Balkan, İ., Batırel, A., Karabay, O., A?alar, C., Akalın, Ş., Alıcı, Ö. ... Yılmaz, H. (2015). Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A multicenter retrospective analysis. Indian Journal of Pharmacology, 47(1), 95-100. https://dx.doi.org/10.4103/0253-7613.150383
dc.identifier.doi10.4103/0253-7613.150383
dc.identifier.endpage100
dc.identifier.issn0253-7613
dc.identifier.issn1998-3751
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage95
dc.identifier.urihttps://dx.doi.org/10.4103/0253-7613.150383
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2693
dc.identifier.volume47
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications
dc.relation.ispartofIndian Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlood Stream Infection
dc.subjectColistin
dc.subjectMonotherapy
dc.subjectMulti Drug Resistant Acinetobacter Spp
dc.titleComparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis
dc.typeArticle

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