Glow in the dark tumor: enhanced near-ir visualization and destruction of cancer with a self-quenched theranostic

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dc.contributor.authorGüler, Selen İrem
dc.contributor.authorAltan, Cem Levent
dc.contributor.authorDemircioğlu, Emine Esma
dc.contributor.authorVerimli, Nihan
dc.contributor.authorAbisoğlu, Beyza
dc.contributor.authorBayraktaroğlu, Çiğdem
dc.contributor.authorErdem, Sultan Sibel
dc.date.accessioned2026-01-30T12:43:29Z
dc.date.available2026-01-30T12:43:29Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractLate diagnosis is one of the major obstacles for the treatment of breast cancer which can be overcome with a system offering sensitive imaging and selective therapeutic effect. In this study, we developed a “dark-bright” multifunctional drug delivery system bringing real-time imaging and non-invasive therapy together. Theranostic ability of the system was delivered by Verteporfin (VP), serving as a fluorescence probe and a photosensitizer. To create a “dark state” system via self-quenching ability of VP, it was immobilized onto the superparamagnetic iron oxide nanoparticle (SPION) surface. Upon cellular uptake of the “dark state” system, release of VP led to fluorescence regain, switching the system to “bright state” after which photodynamic therapy (PDT) was initiated to lead to cell death. Theranostic feature of the system was evaluated in MCF-7 and MDA-MB-231 cell lines. Following internalization, fluorescence signal was increased up to ∼56-fold in MCF-7 cells. The IC50 value decreased ∼20-fold and ∼117-fold in MCF-7 and MDA-MB-231 cell lines, respectively. Moreover, the system significantly inhibited migration in the highly aggressive MDA-MB-231 cell line and induced apoptosis by caspase-3 activation. The developed “dark-bright” system is a promising multifunctional drug delivery vehicle with extraordinary theranostic features for the detection and destruction of micro tumors.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
dc.identifier.citationGüler, S. İ., Altan, C. L., Demircioğlu, E. E., Verimli, N., Abisoğlu, B., Bayraktaroğlu, Ç. ... Erdem, S. S. (2025). Glow in the dark tumor: enhanced near-ir visualization and destruction of cancer with a self-quenched theranostic. European Journal of Pharmaceutics and Biopharmaceutics, 208. http://dx.doi.org/10.1016/j.ejpb.2025.114632
dc.identifier.doi10.1016/j.ejpb.2025.114632
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.pmid39837426
dc.identifier.scopus2-s2.0-85216071549
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ejpb.2025.114632
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13400
dc.identifier.volume208
dc.identifier.wosWOS:001421751000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüler, Selen İrem
dc.institutionauthorDemircioğlu, Emine Esma
dc.institutionauthorVerimli, Nihan
dc.institutionauthorBayraktaroğlu, Çiğdem
dc.institutionauthorErdem, Sultan Sibel
dc.institutionauthorid0000-0002-2219-3830
dc.institutionauthorid0009-0003-5176-8634
dc.institutionauthorid0000-0001-6829-3960
dc.institutionauthorid0000-0002-7318-4053
dc.institutionauthorid0000-0001-6876-3555
dc.language.isoen
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/118S299
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectFluorescence Quenching
dc.subjectNear-IR Imaging
dc.subjectPhotodynamic Therapy
dc.subjectSuperparamagnetic Iron Oxide Nanoparticle
dc.subjectTheranostic Agent
dc.titleGlow in the dark tumor: enhanced near-ir visualization and destruction of cancer with a self-quenched theranostic
dc.typeArticle

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