Prognostic significance of metastatic lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectom

Basit Öğe Kaydı
dc.authorid0000-0002-9815-1848
dc.authorid0000-0002-5823-1704
dc.authorid0000-0003-0128-6947
dc.authorid0000-0003-2357-5387
dc.contributor.authorBilici, Ahmet
dc.contributor.authorBiricik, Fatih Selçuk
dc.contributor.authorŞeker, Mesut
dc.contributor.authorÖven, Başak Bala
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorYıldız, Özcan
dc.contributor.authorÖlmüşçelik, Oktay
dc.contributor.authorHamdard, Jamshid
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorÇakır, Aslı
dc.contributor.authorKapran, Yersu
dc.contributor.authorBalık, Emre
dc.contributor.authorÖncel, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:47Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:47Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Anabilim Dalı
dc.descriptionWOS: 000464383800005
dc.descriptionPubMed ID: 30870846
dc.description.abstractBackground: Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the prognostic significance of metastatic lymph node ratio (MLNR) and compare it to the number of lymph node metastasis in pN3 gastric cancer. Methods: We retrospectively analyzed 207 patients with pN3 gastric cancer who had undergone radical gastrectomy. Prognostic factors and MLNR were evaluated by univariate and multivariate analysis. Results: An MLNR of 0.75 was found to be the best cut-off value to determine the prognosis of patients with pN3 gastric cancer (p = 0.001). The MLNR was significantly higher in patients with large-sized and undifferentiated tumors, vascular, lymphatic and perineural invasion, and total gastrectomy. In multivariate analysis, MLNR (p = 0.041), tumor differentiation (p = 0.046), and vascular invasion (p = 0.012) were found to be independent prognos-tic factors for disease-free survival, while both MLNR (p <0.001) and pN stage (p = 0.002) were independent prognostic indicators, as was tumor size, for overall survival. There was significant difference with respect to the recurrence patterns between MLNR groups. Lymph node and peritoneal recurrences were significantly higher in patients with MLNR> 0.75 compared to the MLNR <0.75 group (p <0.05). However, recurrence patterns were similar between pN3a and pN3b. Conclusion: Our results showed that MLNR was a useful indicator to determine the prognosis and recurrence patterns of patients with radically resected gastric cancer. Moreover, MLNR is a beneficial and reliable technique for evaluating lymph node metastasis.
dc.identifier.citationBilici, A., Biricik, F. S., Şeker, M., Öven, B. B., Ölmez, Ö. F. Yıldız, Ö. ... Öncel, M. (2019). Prognostic significance of metastatic lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectom. Oncology Research and Treatment, 42(4), 204-211. https://dx.doi.org/10.1159/000496746
dc.identifier.doi10.1159/000496746
dc.identifier.endpage211
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage204
dc.identifier.urihttps://dx.doi.org/10.1159/000496746
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1766
dc.identifier.volume42
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGastric Cancer
dc.subjectMetastatic Lymph Node Ratio
dc.subjectN3
dc.subjectPrognosis
dc.titlePrognostic significance of metastatic lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectom
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Bilici, Ahmet-2019.pdf
Boyut:
373.61 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu