Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

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dc.authorid0000-0002-8215-3638
dc.contributor.authorÇakır, Ahsen
dc.contributor.authorBozali, Kübra
dc.contributor.authorÇelikten, Mert
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorŞahan, Ebru
dc.contributor.authorDurdu, Bülent
dc.contributor.authorSümbül, Bilge
dc.contributor.authorKoçyiğit, Abdurrahim
dc.date.accessioned2023-02-24T07:19:59Z
dc.date.available2023-02-24T07:19:59Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi Ana Bilim Dalı
dc.description.abstractSince most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.
dc.description.sponsorshipBezmialem Vakif Universityen_US
dc.identifier.citationÇakır, A., Bozali, K., Çelikten, M., Güler, Eray M., Şahan, E., Durdu, B. ... Koçyiğit, A. (2023). Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study. Journal of Biochemical and Molecular Toxicology, 37(1). https://dx.doi.org/10.1002/jbt.23240
dc.identifier.doi10.1002/jbt.23240
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue1
dc.identifier.pmid36214215
dc.identifier.scopus2-s2.0-85139630373
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.23240
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10523
dc.identifier.volume37
dc.identifier.wos000865443800001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikten, Mert
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntidepressive
dc.subjectFluoxetine
dc.subjectImipenem
dc.subjectInflammation
dc.subjectSepsis
dc.titleExamination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study
dc.typeArticle

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