Needle-based optical coherence tomography for the detection of prostate cancer: A visual and quantitative analysis in 20 patients

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dc.authorid0000-0002-6308-1763
dc.contributor.authorMuller, Berrend G.
dc.contributor.authorvan Kollenburg, Rob A. A.
dc.contributor.authorSwaan, Abel
dc.contributor.authorZwartkruis, Evita C. H.
dc.contributor.authorBrandt, Martin J.
dc.contributor.authorWilk, Leah S.
dc.contributor.authorAlmasian, Mitra
dc.contributor.authorSchreurs, A. Wim
dc.contributor.authorFaber, Dirk J.
dc.contributor.authorRozendaal, L. Rence
dc.contributor.authorVis, Andre N.
dc.contributor.authorNieuwenhuijzen, Jakko A.
dc.contributor.authorvan Moorselaar, Jeroen R. J. A.
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorde Bruin, Daniel Martijn
dc.contributor.authorvan Leeuwen, Ton G.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:22Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000444019900009
dc.descriptionPubMed ID: 30094972
dc.description.abstractDiagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation were performed. OCT can reliably differentiate between fat, cystic, and regular atrophy and benign glands. The overall sensitivity and specificity for malignancy detection was 79% and 88% for reviewer 1 and 88% and 81% for reviewer 2. Quantitative analysis for differentiation between stroma and malignancy showed a significant difference (4.6mm(-1) versus 5.0mm(-1) Mann-Whitney U-test p <0.0001). A Kruskal-Wallis test showed a significant difference in median attenuation coefficient between stroma, inflammation, Gleason 3, and Gleason 4 (4.6, 4.1, 5.9, and 5.0mm(-1), respectively). However, attenuation coefficient varied per patient and a related-samples Wilcoxon signed-rank test showed no significant difference per patient (p = 0.17). This study confirmed the one to one correlation of histopathology and OCT. Precise matching showed that most histological tissues categories in the prostate could be distinguished by their unique pattern in OCT images. In addition, the optical attenuation coefficient can play a role in the differentiation between stroma and malignancy; however, a per patient analysis of the optical attenuation coefficient did not show a significant difference. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
dc.description.sponsorshipCure for Cancer Foundationen_US
dc.description.sponsorshipThis study was funded by an unrestricted research grant from the Cure for Cancer Foundation.en_US
dc.identifier.citationMuller, B., van Kollenburg, R., Swaan, A., Zwartkruis, E., Brandt, M., Wilk, L. ... van Leeuwen, T. (2018). Needle-based optical coherence tomography for the detection of prostate cancer: A visual and quantitative analysis in 20 patients. Journal of Biomedical Optics, 23(8). https://dx.doi.org/10.1117/1.JBO.23.8.086001
dc.identifier.doi10.1117/1.JBO.23.8.086001
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.issue8
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1117/1.JBO.23.8.086001
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1961
dc.identifier.volume23
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpie-Soc Photo-Optical Instrumentation Engineers
dc.relation.ispartofJournal of Biomedical Opticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/deed.en_US*
dc.subjectOptical Coherence Tomography
dc.subjectProstate
dc.subjectNeedle-Based
dc.subjectValidation
dc.subjectHistopathology
dc.subjectProstate Cancer
dc.titleNeedle-based optical coherence tomography for the detection of prostate cancer: A visual and quantitative analysis in 20 patients
dc.typeArticle

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