Comparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey

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dc.authorid0000-0002-7950-2067
dc.authorid0000-0002-8003-1952
dc.contributor.authorSoysal, Ahmet
dc.contributor.authorGönüllü, Erdem
dc.contributor.authorArslan, Hüseyin
dc.contributor.authorKibar, Büşra Sultan
dc.contributor.authorPop, Serdar
dc.contributor.authorYurttaş, Gözde Nur
dc.contributor.authorDemirbacak, Hacer
dc.contributor.authorÜnal, Füsun
dc.contributor.authorÖktem, Sedat
dc.contributor.authorAtıcı, Serkan
dc.contributor.authorYücel Şen, Arife Derda
dc.contributor.authorKarabayır, Nalan
dc.contributor.authorKaraböcüoğlu, Metin
dc.date.accessioned2021-04-05T06:56:41Z
dc.date.available2021-04-05T06:56:41Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractSince the first report of COVID-19 in December 2019, little is known about therapeutic usage of hydroxychloroquine in pediatric patients with COVID-19. We retrospectively retrieved data for SARS-CoV-2 PCR positive pediatric patients from 20 hospitals in 8 different cities in Turkey. We obtained patients' epidemiological, clinical, laboratory features and drugs used for treatment of COVID-19. 237 nasopharyngeal swab SARS-CoV-2 PCR positive children were included into the study from March 26 to June 20, 2020. The mean age of asymptomatic children (118±62 months) was found to be higher than that of symptomatic children (89±69 months). Symptomatic children had a significantly lower mean lymphocyte count and higher mean CRP, D-dimer value, procalcitonin and LDH than asymptomatic children in univariate analysis. Out of 156 children, 78 (50%) children received Hydroxychloroquine-containing regimen, 15 of them were treated with hydroxychloroquine + azithromycin + oseltamivir, 44 were treated with hydroxychloroquine + azithromycin and 21 were only treated with hydroxychloroquine. Among the 156 patients who received medical treatment, 90 (58%) patients had pre and/or post-treatment ECG performed upon them. However, none of them either reported ECG abnormalities or a need for discontinuation of hydroxychloroquine because of adverse drug reaction.
dc.identifier.citationSoysal, A., Gönüllü, E., Arslan, H., Kibar, B. S., Pop, S., Yurttaş, G. N. ... Karaböcüoğlu, M. (2021). Comparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey. Japanese Journal of Infectious Diseases, 74(4), 273-279. https://dx.doi.org/10.7883/yoken.JJID.2020.781
dc.identifier.doi10.7883/yoken.JJID.2020.781
dc.identifier.endpage279
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage273
dc.identifier.urihttps://dx.doi.org/10.7883/yoken.JJID.2020.781
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6684
dc.identifier.volume74
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNational Institute of Infectious Diseases
dc.relation.ispartofJapanese Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydroxychloroquine
dc.subjectSARS-CoV-2
dc.subjectTurkey
dc.titleComparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey
dc.typeArticle

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