Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon

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dc.authorid0000-0002-4479-2586
dc.authorid0000-0003-0352-1947
dc.authorid0000-0002-2752-1223
dc.contributor.authorSibai, Mustafa
dc.contributor.authorAltuntaş, Ebru
dc.contributor.authorYıldırım, Berna
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorDemircan, Turan
dc.date.accessioned2020-11-16T06:51:45Z
dc.date.available2020-11-16T06:51:45Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractWith a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the blind mole-rat (Spalax leucodon), a subterranean mammalian, has emerged as an exceptional model organism due to its astonishing features such as remarkable longevity, hypoxia and hypercapnia tolerance, and cancer resistance. The microbiome has been found to be a vital parameter for cellular physiology and it is safe to assume that it has an impact on life expectancy. Although the unique characteristics ofSpalaxmake it an ideal experimental model for longevity research, there is limited knowledge of the bacterial composition ofSpalaxmicrobiome, which limits its in-depth utilization. In this study, using 16S rRNA amplicon sequencing, we report the gut and skin bacterial structure ofSpalaxfor the first time. The diversity between fecal and skin samples was manifested in the distant clustering, as revealed by beta diversity analysis. Importantly, the longevity-linked Muribaculaceae bacterial family was found to be the dominating bacterial taxa inSpalaxfecal samples. These new findings contribute toward further development ofSpalaxas a model for longevity research and potential linkages between microbiome composition and longevity.
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID) Office of Cyber Infrastructure and Computational Biology (OCICB) in Bethesda, MDen_US
dc.identifier.citationSibai, M., Altuntaş, E., Yıldırım, B., Öztürk, G., Yıldırım, S. ve Demircan, T. (2020). Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon. OMICS: A Journal of Integrative Biology, 24(10), 592-601. https://dx.doi.org/10.1089/omi.2020.0116
dc.identifier.doi10.1089/omi.2020.0116
dc.identifier.endpage601
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.issue10
dc.identifier.scopusqualityQ2
dc.identifier.startpage592
dc.identifier.urihttps://dx.doi.org/10.1089/omi.2020.0116
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6031
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofOMICS: A Journal of Integrative Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMicrobiome
dc.subjectLongevity
dc.subjectAging Research
dc.subjectSpalax
dc.subjectMuribaculaceae
dc.subject16S rRNA Sequencing
dc.titleMicrobiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon
dc.typeArticle

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