Transfer and integration of breast milk stem cells to the brain of suckling pups

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dc.authorid0000-0002-6393-1465
dc.authorid0000-0001-9037-5217
dc.authorid0000-0003-0352-1947
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorYiğit, Esra Nur
dc.contributor.authorVatandaşlar, Emre
dc.contributor.authorErdoğan, Ender
dc.contributor.authorÖztürk, Gürkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:10Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:10Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000445336600057
dc.descriptionPubMed ID: 30250150
dc.description.abstractBeside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female mice (GFP+) were used as foster mothers to breastfeed wildtype newborn pups. One week and two months after the birth, blood samples and brains of the sucklings were analyzed to detect presence of GFP+ cells by fluorescence activated cell sorting, polymerase chain reaction and immunohistochemistry on the brain sections and optically cleared brains. The tests confirmed that maternal cells were detectable in the blood and the brain of the pups and that they differentiated into both neuronal and glial cell types in the brain. This phenomenon represents breastfeeding - induced microchimerism in the brain with functional implications remain to be understood.
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) [114R078]en_US
dc.description.sponsorshipThis project was supported by "The Scientific and Technological Research Council of Turkey" (TUBITAK) with a grant number 114R078.en_US
dc.identifier.citationAydın, M. Ş., Yiğit, E., Vatandaşlar, E., Erdoğan, E. ve Öztürk, G. (2018). Transfer and integration of breast milk stem cells to the brain of suckling pups. Scientific Reports, 8. https://dx.doi.org/10.1038/s41598-018-32715-5
dc.identifier.doi10.1038/s41598-018-32715-5
dc.identifier.issn2045-2322
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-018-32715-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1903
dc.identifier.volume8
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectChimerism
dc.subjectPregnancy
dc.subjectFetal Microchimerism
dc.titleTransfer and integration of breast milk stem cells to the brain of suckling pups
dc.typeArticle

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