Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis

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dc.authorid0000-0002-8084-7855
dc.authorid0000-0002-7059-1884
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorKeskin, İlknur
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorÖz Ergene, Burçin
dc.contributor.authorKurtul, Ekin
dc.contributor.authorÖzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.contributor.authorSaltan, Gülçin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:36Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:36Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractAlchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100 mg/kg and 200 mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200 mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties.
dc.identifier.citationÖzbek, H., Bahadır Acıkara, Ö., Keskin, İ., Kırmızı, N. İ., Özbilgin, S., Öz Ergene, B. ... Saltan, G. (2017). Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis. Biomedicine and Pharmacotherapy, 86, 172-176. https://dx.doi.org/10.1016/j.biopha.2016.12.005
dc.identifier.doi10.1016/j.biopha.2016.12.005
dc.identifier.endpage176
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.scopusqualityQ1
dc.identifier.startpage172
dc.identifier.urihttps://hdl.handle.net/20.500.12511/860
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2016.12.005
dc.identifier.volume86
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Masson SAS
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlchemilla Mollis
dc.subjectAntidiabetic Activity
dc.subjectHepatoprotective Activity
dc.subjectMice
dc.subjectRats
dc.titleEvaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
dc.typeArticle

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