Parietal memory network and memory encoding versus retrieval impairments in pd-mci patients: a hippocampal volume and cortical thickness study

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dc.contributor.authorŞahin, Serhat
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorYuluğ, Burak
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2025-08-28T13:34:33Z
dc.date.available2025-08-28T13:34:33Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective: The pathophysiology behind memory impairment in Parkinson's Disease Mild Cognitive Impairment (PD-MCI) is unclear. This study aims to investigate the hippocampal and cortical atrophy patterns in PD-MCI patients with different types of memory impairments, categorized as Retrieval Failure (RF) and Encoding Failure (EF). Methods: The study included 16 healthy controls (HC) and 34 PD-MCI patients, divided into RF (N = 18) and EF (N = 16) groups based on their Verbal Memory Processes Test (VMPT) scores, including spontaneous recall, recognition, and Index of Sensitivity to Cueing (ISC). Hippocampal subfields and cortical thicknesses were measured using the FreeSurfer software for automatic segmentation. Results: Compared to the HC group, the EF group exhibited significant atrophy in the left lateral occipital region and the right caudal middle frontal, superior temporal, and inferior temporal regions (p⟨0.05). The RF group displayed significant atrophy in the left lateral occipital, middle temporal, and precentral regions, as well as the right pars orbitalis and superior frontal regions (p⟨0.05). Hippocampal subfield analysis revealed distinct volume differences between HC-EF and RF-EF groups, with significant reductions in the CA1, CA3, and CA4 subregions in the EF group, but no differences between HC and RF groups (p > 0.05). Conclusion: Gray matter atrophy patterns differ in PD-MCI patients with encoding and retrieval memory impairments. The significant hippocampal atrophy in the EF group, particularly in the CA subregions, highlights its potential role in disease progression and memory decline. Additionally, the convergence of atrophy in the lateral occipital cortex across both RF and EF groups suggests the involvement of the Parietal Memory Network (PMN) in PD-related memory impairment.
dc.identifier.citationŞahin, S., Velioğlu, H. A., Yuluğ, B., Bayraktaroğlu, Z., Yıldırım, S. ve Hanoğlu, L. (2024). Parietal memory network and memory encoding versus retrieval impairments in pd-mci patients: a hippocampal volume and cortical thickness study. CNS Neuroscience and Therapeutics, 30(10). http://dx.doi.org/10.1111/cns.70062
dc.identifier.doi10.1111/cns.70062
dc.identifier.issn1755-5930
dc.identifier.issn1755-5949
dc.identifier.issue10
dc.identifier.pmid39380180
dc.identifier.scopus2-s2.0-85206024999
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1111/cns.70062
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13040
dc.identifier.volume30
dc.identifier.wosWOS:001331141300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Serhat
dc.institutionauthorVelioğlu, Halil Aziz
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.institutionauthorYıldırım, Süleyman
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorid0000-0002-2306-5937
dc.institutionauthorid0000-0001-5118-4776
dc.institutionauthorid0000-0002-2752-1223
dc.institutionauthorid0000-0003-4292-5717
dc.language.isoen
dc.relation.ispartofCNS Neuroscience and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCortical Thickness
dc.subjectEncoding Failure
dc.subjectGray Matter Volume
dc.subjectHippocampus
dc.subjectParietal Memory Network
dc.subjectParkinson's Disease-Mild Cognitive Impairment
dc.subjectRetrieval Failure
dc.titleParietal memory network and memory encoding versus retrieval impairments in pd-mci patients: a hippocampal volume and cortical thickness study
dc.typeArticle

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