Age-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion

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dc.authorid0000-0002-9476-8488
dc.authorid0000-0001-6711-8271
dc.authorid0000-0002-6242-3709
dc.authorid0000-0002-2657-3515
dc.authorid0000-0001-6494-8923
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorAydınlı, Fatmagül İlayda
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorBeker, Merve
dc.contributor.authorBaygül, Oğuzhan
dc.contributor.authorÇağlayan, Aysun
dc.contributor.authorPopa-Wagner, Aurel
dc.contributor.authorDoeppner, Thorsten R.
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2024-01-17T10:31:57Z
dc.date.available2024-01-17T10:31:57Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIschemic stroke is the leading cause of death and disability. Although stroke mainly affects aged individuals, animal research is mostly one on young rodents. Here, we examined the development of ischemic injury in young (9-12-week-old) and adult (72-week-old) C57BL/6 and BALB/c mice exposed to 30 min of intraluminal middle cerebral artery occlusion (MCAo). Post-ischemic reperfusion did not differ between young and adult mice. Ischemic injury assessed by infarct area and blood-brain barrier (BBB) integrity assessed by IgG extravasation analysis was smaller in adult compared with young mice. Microvascular viability and neuronal survival assessed by CD31 and NeuN immunohistochemistry were higher in adult than young mice. Tissue protection was associated with stronger activation of cell survival pathways in adult than young mice. Microglial/macrophage accumulation and activation assessed by F4/80 immunohistochemistry were more restricted in adult than young mice, and pro- and anti-inflammatory cytokine and chemokine responses were reduced by aging. By means of liquid chromatography-mass spectrometry, we identified a hitherto unknown proteome profile comprising the upregulation of glycogen degradation-related pathways and the downregulation of mitochondrial dysfunction-related pathways, which distinguished post-ischemic responses of the aged compared with the young brain. Our study suggests that aging increases the brain's resilience against ischemic injury.
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.identifier.citationBeker, M. Ç., Aydınlı, F. İ., Çağlayan, A. B., Beker, M., Baygül, O., Çağlayan, A. ... Kılıç, E. (2023). Age-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion. Molecular Neurobiology, 60(8), 4359-4372. https://dx.doi.org/10.1007/s12035-023-03353-4
dc.identifier.doi10.1007/s12035-023-03353-4
dc.identifier.endpage4372
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.issue8
dc.identifier.pmid37093494
dc.identifier.scopus2-s2.0-85153352875
dc.identifier.scopusqualityQ1
dc.identifier.startpage4359
dc.identifier.urihttps://dx.doi.org/10.1007/s12035-023-03353-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12160
dc.identifier.volume60
dc.identifier.wos000974956900002en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorAydınlı, Fatmagül İlayda
dc.institutionauthorÇağlayan, Ahmet Burak
dc.institutionauthorBaygül, Oğuzhan
dc.institutionauthorÇağlayan, Aysun
dc.institutionauthorKılıç, Ertuğrul
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAging
dc.subjectIschemia
dc.subjectNeuroinfammation
dc.subjectNeuronal Injury
dc.subjectProteomics
dc.subjectStroke Recovery
dc.titleAge-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion
dc.typeArticle

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