Modulation of protein-protein interactions for the development of effective therapeutics - from a joint perspective of experiment and computation

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dc.authorid0000-0001-5950-3436
dc.contributor.authorMoreira, Irina Sousa
dc.contributor.authorŞensoy, Özge
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:46Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.descriptionWOS: 000441070600001
dc.descriptionPubMed ID: 30062954
dc.description.abstractMany proteins present in living organisms act as obligate oligomers – that is to say - they require other protein partners to function properly. Oligomerization does not only lead to the formation of physical interactions, which are required to hold individual protomers together in these assemblies, but it also triggers the cross-talk within the oligomer, so that individual protomers can regulate and modulate each other’s function in the form of either inhibition or activation. Consequently, this notion has changed the classical “single-target” pharmacology to “multi-target” one, urging the development of novel approaches in the field of drug discovery. In general, modulation of the function of a particular complex can be done by means of small-molecules developed specifically to target the interface between the protomers. This requires atomistic-level knowledge regarding the structure and dynamics of the system. As such, numerous experimental techniques were established in order to identify the partners in these assemblies. However, data solely based on these experimental techniques do not provide a mechanistic insight on the system as it cannot provide atomistic-level information per se regarding inherent allosteric interactions that govern the function of the complex. In this respect, computational methods act as indispensable tools to complement and to provide careful experimental data interpretation. The combination of these two worlds paves the way to the development of new, efficient and specific therapeutics.
dc.identifier.citationMoreira, I. S. ve Şensoy, Ö. (2018). Modulation of protein-protein ınteractions for the development of effective therapeutics - from a joint perspective of experiment and computation. Current Topics in Medicinal Chemistry, 18(8), 645-646. https://dx.doi.org/10.2174/156802661808180718151704
dc.identifier.doi10.2174/156802661808180718151704
dc.identifier.endpage646
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.issue8
dc.identifier.scopusqualityQ1
dc.identifier.startpage645
dc.identifier.urihttps://dx.doi.org/10.2174/156802661808180718151704
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2280
dc.identifier.volume18
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.relation.ispartofCurrent Topics in Medicinal Chemistryen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMicroRNAs
dc.subjectRNA
dc.subjectEndogenous RNAs
dc.subjectProtein MDMX
dc.subjectProtein MDM2
dc.subjectProtein Binding
dc.titleModulation of protein-protein interactions for the development of effective therapeutics - from a joint perspective of experiment and computation
dc.typeEditorial

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