Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release

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dc.authorid0000-0001-6829-3960
dc.authorid0000-0001-6876-3555
dc.contributor.authorDemiral, Ayşegül
dc.contributor.authorGoralı, S. İrem
dc.contributor.authorYılmaz, Hülya
dc.contributor.authorVerimli, Nihan
dc.contributor.authorÇulha, Mustafa
dc.contributor.authorErdem, Sultan Sibel
dc.date.accessioned2022-06-24T09:58:31Z
dc.date.available2022-06-24T09:58:31Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Moleküler Tıp ve Biyoteknoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractDestruction of drug resistant and invisible micro-tumors requires innovative screening and treatment modalities. Theranostic nanosystems offering multimodal imaging and therapy are attractive platforms with potential to make micro-tumors visible to clinicians. Gold nanoparticles (AuNPs) are intrinsic theranostic agents and act as fluorescence quenchers. They can be easily transformed to multimodal imaging and combination therapy agents by combining them with various adjuvant therapies such as photodynamic therapy. In this study, we developed a highly specific, hybrid theranostic agent that is only activated when it meets with its stimuli at the site of interest. Surface-coated AuNPs were modified with Cathepsin B cleavable peptide (stimuli responsive linker) and Verteporfin (photosensitizer and fluorescence imaging agent). Unless the theranostic system meets with the internal stimuli in tumor cells, fluorescence is quenched due to AuNP-Verteporfin and Verteporfin-Verteporfin interactions. Following cellular internalization of the theranostic agent, fluorescence is gained by Cathepsin B cleavage and phototoxicity is initiated by light. The system was efficiently internalized by SKOV-3 cells and demonstrated high specificity towards its stimuli. In comparison to Verteporfin, ?14-fold fluorescence increase, 81% fluorescence recovery and comparable toxicity were achieved. The system is a promising candidate for multimodal imaging and dual treatment to destroy the micro-tumors.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)-119S219en_US
dc.identifier.citationDemiral, A., Goralı, S. İ., Yılmaz, H., Verimli, N., Çulha, M. ve Erdem, S. S. (2022). Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release. European Journal of Pharmaceutics and Biopharmaceutics, 177, 9-23. http://doi.org/10.1016/j.ejpb.2022.05.021
dc.identifier.doi10.1016/j.ejpb.2022.05.021
dc.identifier.endpage23
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.pmid35671914
dc.identifier.scopus2-s2.0-85131749341
dc.identifier.scopusqualityQ1
dc.identifier.startpage9
dc.identifier.urihttp://doi.org/10.1016/j.ejpb.2022.05.021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9538
dc.identifier.volume177
dc.identifier.wos000812921900002en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemiral, Ayşegül
dc.institutionauthorGoralı, S. İrem
dc.institutionauthorVerimli, Nihan
dc.institutionauthorErdem, Sultan Sibel
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCathepsin B
dc.subjectFluorescence Imaging
dc.subjectFluorescence Quenching
dc.subjectGold Nanoparticle
dc.subjectHybrid Theranostic Agent
dc.subjectMultimodal Imaging
dc.subjectNear-IR Fluorescent Dye
dc.subjectPhotodynamic Therapy
dc.subjectVerteporfin
dc.titleStimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release
dc.typeArticle

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