Investigation of hemispheric asymmetry in alzheimer’s disease patients during resting state revealed by fnirs

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dc.contributor.authorMızrak, Hazel Gül
dc.contributor.authorDikmen, Merve
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorŞakul, Bayram Ufuk
dc.date.accessioned2025-06-23T09:18:03Z
dc.date.available2025-06-23T09:18:03Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.description.abstractAlzheimer's disease (AD) is characterized by the gradual deterioration of brain structures and changes in hemispheric asymmetry. Meanwhile, healthy aging is associated with a decrease in functional hemispheric asymmetry. In this study, functional connectivity analysis was used to compare the functional hemispheric asymmetry in eyes-open resting-state fNIRS data of 16 healthy elderly controls (mean age: 60.4 years, MMSE (Mini-Mental State Examination): 27.3 ± 2.52) and 14 Alzheimer's patients (mean age: 73.8 years, MMSE: 22 ± 4.32). Increased interhemispheric functional connectivity was found in the premotor cortex, supplementary motor cortex, primary motor cortex, inferior parietal cortex, primary somatosensory cortex, and supramarginal gyrus in the control group compared to the AD group. The study revealed that the control group had stronger interhemispheric connectivity, leading to a more significant decrease in hemispheric asymmetry than the AD group. The results show that there is a difference in interhemispheric functional connections at rest between the Alzheimer's group and the control group, suggesting that functional hemispheric asymmetry continues in Alzheimer's patients.
dc.identifier.citationMızrak, H. G., Dikmen, M., Hanoğlu, L. ve Şakul, B. U. (2024). Investigation of hemispheric asymmetry in alzheimer’s disease patients during resting state revealed by fnirs. Scientific Reports, 14(1). http://dx.doi.org/10.1038/s41598-024-62281-y
dc.identifier.doi10.1038/s41598-024-62281-y
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid38862632
dc.identifier.scopus2-s2.0-85195633944
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-024-62281-y
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12989
dc.identifier.volume14
dc.identifier.wosWOS:001245305300061
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMızrak, Hazel Gül
dc.institutionauthorDikmen, Merve
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorŞakul, Bayram Ufuk
dc.institutionauthorid0000-0003-1382-3164
dc.institutionauthorid0000-0002-6884-5021
dc.institutionauthorid0000-0003-4292-5717
dc.institutionauthorid0000-0002-5539-2342
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer Disease
dc.subjectBrain Mapping
dc.subjectCase-Control Studies
dc.subjectFunctional Laterality
dc.subjectAged
dc.titleInvestigation of hemispheric asymmetry in alzheimer’s disease patients during resting state revealed by fnirs
dc.typeArticle

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