Does gross total resection improve progression-free and overall survival in pediatric intracranial ependymomas? Single-center clinical experience of 61 cases

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dc.authorid0000-0003-1447-9051
dc.contributor.authorNarin, Fırat
dc.contributor.authorBahadır, Sinan
dc.contributor.authorHanalioğlu, Şahin
dc.contributor.authorKarakaya, Dicle
dc.contributor.authorBaşar, İbrahim
dc.contributor.authorIşıkay, İlkay
dc.contributor.authorSöylemezoğlu, Figen
dc.contributor.authorAkalan, Nejat
dc.contributor.authorBilginer, Burçak
dc.date.accessioned2022-10-26T12:25:43Z
dc.date.available2022-10-26T12:25:43Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To share our clinical experience of 25 years and identify prognostic factors for progression-free and overall survival in pediatric intracranial ependymomas. METHODS: In total, 61 children who were treated be-tween 1995 and 2020 in a single institution were included in the study. Medical records of the patients were retro-spectively reviewed to obtain and analyze the following data: patient age at first surgery, sex, presenting symptoms, hydrocephalus and any invasive treatment, anatomic site, extent of resection, pathologic grade, time to progression, and time to death. Progression-free and overall survival rates and affecting factors were analyzed by Kaplan-Meier method. RESULTS: Dysphagia, number of surgeries, and spinal seeding were associated with progression free and overall survival in univariate analysis. The extent of resection, World Health Organization grade, and visual problems were also associated with progression whereas sex was associated with overall survival. Cox regression identified the extent of resection and single surgery as an indepen-dent prognostic factor for progression-free survival. No independent factor was found for overall survival. CONCLUSIONS: This single center experience of 25 years confirms the beneficial effect of gross total resection on disease progression. Although spinal seeding seems to affect survival rates, greater number of cases are needed to reveal its full effect.
dc.identifier.citationNarin, F., Bahadır, S., Hanalioğlu, Ş., Karakaya, D., Başar, İ., Işıkay, İ. ... Bilginer, B. (2022). Does gross total resection improve progression-free and overall survival in pediatric intracranial ependymomas? Single-center clinical experience of 61 cases. World Neurosurgery, 165, E469-E478. https://doi.org/10.1016/j.wneu.2022.06.082
dc.identifier.doi10.1016/j.wneu.2022.06.082
dc.identifier.endpageE478
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid35772712
dc.identifier.scopus2-s2.0-85134576134
dc.identifier.scopusqualityQ1
dc.identifier.startpageE469
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2022.06.082
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9885
dc.identifier.volume165
dc.identifier.wos000864471400021en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkalan, Nejat
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChildhood
dc.subjectEpendymoma
dc.subjectIntracranial
dc.subjectPrognostic Factors
dc.subjectSurvival
dc.titleDoes gross total resection improve progression-free and overall survival in pediatric intracranial ependymomas? Single-center clinical experience of 61 cases
dc.typeArticle

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