Cellular interactions with bacterial cellulose: Polycaprolactone nanofibrous scaffolds produced by a portable electrohydrodynamic gun for point-of-need wound dressing

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dc.authorid0000-0002-0368-4028
dc.contributor.authorAydoğdu, Mehmet Onur
dc.contributor.authorAltun, Esra
dc.contributor.authorCrabbe-Mann, Maryam
dc.contributor.authorBrako, Francis
dc.contributor.authorKoç, Fatma
dc.contributor.authorÖzen, Güneş
dc.contributor.authorKuruca, Serap Erdem
dc.contributor.authorEdirisinghe, Ursula
dc.contributor.authorLuo, C. J.
dc.contributor.authorGündüz, Oğuzhan
dc.contributor.authorEdirisinghe, Mohan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:07Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:07Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000444951400014
dc.descriptionPubMed ID: 29806201
dc.description.abstractElectrospun nanofibrous scaffolds are promising regenerative wound dressing options but have yet to be widely used in practice. The challenge is that nanofibre productions rely on bench-top apparatuses, and the delicate product integrity is hard to preserve before reaching the point of need. Timing is critically important to wound healing. The purpose of this investigation is to produce novel nanofibrous scaffolds using a portable, hand-held gun, which enables production at the wound site in a time-dependent fashion, thereby preserving product integrity. We select bacterial cellulose, a natural hydrophilic biopolymer, and polycaprolactone, a synthetic hydrophobic polymer, to generate composite nanofibres that can tune the scaffold hydrophilicity, which strongly affects cell proliferation. Composite scaffolds made of 8 different ratios of bacterial cellulose and polycaprolactone were successfully electrospun. The morphological features and cell-scaffold interactions were analysed using scanning electron microscopy. The biocompatibility was studied using Saos-2 cell viability test. The scaffolds were found to show good biocompatibility and allow different proliferation rates that varied with the composition of the scaffolds. A nanofibrous dressing that can be accurately moulded and standardised via the portable technique is advantageous for wound healing in practicality and in its consistency through mass production.
dc.description.sponsorshipUCLen_US
dc.description.sponsorshipThe authors wish to thank UCL for part supporting the visits of Esra Altun and Mehmet Onur Aydogdu.en_US
dc.identifier.citationAydoğdu, M. O., Altun, E., Crabbe-Mann, M., Brako, F., Koç, F., Özen, G. ... Edirisinghe, M. (2018). Cellular interactions with bacterial cellulose: Polycaprolactone nanofibrous scaffolds produced by a portable electrohydrodynamic gun for point-of-need wound dressing. International Wound Journal, 15(5), 789-797. https://dx.doi.org/10.1111/iwj.12929
dc.identifier.doi10.1111/iwj.12929
dc.identifier.endpage797
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage789
dc.identifier.urihttps://dx.doi.org/10.1111/iwj.12929
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1885
dc.identifier.volume15
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Wound Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBacterial Cellulose
dc.subjectElectrohydrodynamic
dc.subjectElectrospinning
dc.subjectPolycaprolactone
dc.subjectWound Dressing
dc.titleCellular interactions with bacterial cellulose: Polycaprolactone nanofibrous scaffolds produced by a portable electrohydrodynamic gun for point-of-need wound dressing
dc.typeArticle

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