Effect of mesenchymal stem cells therapy in experimental kaolin induced syringomyelia model

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dc.contributor.authorBal, Ercan
dc.contributor.authorHanalioğlu, Şahin
dc.contributor.authorKöprü, Çağla Zübeyde
dc.contributor.authorKöse, Sevil
dc.contributor.authorBaşak, Ahmet T.
dc.contributor.authorPehlivan, Sibel
dc.contributor.authorÇetinkaya, Duygu
dc.contributor.authorPurali, Nuhan
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorBozkurt, Gökhan
dc.date.accessioned2021-04-05T10:22:11Z
dc.date.available2021-04-05T10:22:11Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: Syringomyelia is a pathological cavitation of the spinal cord. In this study, we examined whether a syrinx cavity would limit itself with axonal regeneration and stem cell activity in the cavity, and we evaluated subjects on a functional basis.Methods: Groups were designated as kaolin, trauma, kaolin-trauma, and saline groups. Also divided out of the syringomyelia treated groups were those given human mesenchymal stem cells (hMSCs). All groups were evaluated with immunohistochemistry, electron microscopy, confocal microscopy and functionally.Results: The kaolin-trauma group had a significant correction of BBB score with hMSCs therapy. The syrinx cavity measurements showed significant improvement in groups treated with hMSCs. The tissue surrounding the syrinx cavity, however, appeared to be better organized in groups treated with hMSCs. The process of repair and regeneration of damaged axons in the lesion were more improved in groups treated with hMSCs. Using confocal microscopy, fluorescence of hMSCs was observed in the central canal, in the ependymal tissue, and around the lesion.Conclusions: It was concluded that axonal repair accelerated in groups receiving stem cells, and thus, stem cells may be effective in recovery of neural tissue and myelin damage in syringomyelia.
dc.identifier.citationBal, E., Hanalioğlu, Ş., Köprü, Ç. Z., Köse, S., Başak, A. T., Pehlivan, S. ... Bozkurt, G. (2022). Effect of mesenchymal stem cells therapy in experimental kaolin induced syringomyelia model. Journal of Neurosurgical Sciences, 66(1), 40-48. https://dx.doi.org/10.23736/S0390-5616.20.05026-2
dc.identifier.doi10.23736/S0390-5616.20.05026-2
dc.identifier.issn0390-5616
dc.identifier.issn1827-1855
dc.identifier.pmid33056946
dc.identifier.scopus2-s2.0-85125014643
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.23736/S0390-5616.20.05026-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6690
dc.identifier.wos000761303300004en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMinerva Medica
dc.relation.ispartofJournal of Neurosurgical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectConfocal Microscopy
dc.subjectKaolin
dc.subjectMesenchymal Stem Cell
dc.subjectSyringomyelia
dc.titleEffect of mesenchymal stem cells therapy in experimental kaolin induced syringomyelia model
dc.typeArticle

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