Hypothesis: Co-transfer of genuine embryos and implantation promoting compounds via artificial containers improve endometrium receptivity

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dc.contributor.authorÇelik, Önder
dc.contributor.authorAcet, Mustafa
dc.contributor.authorÇelik, Sudenaz
dc.contributor.authorŞahin, Levent
dc.contributor.authorKoç, Önder
dc.contributor.authorÇelik, Nilufer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:42Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000403731600017
dc.descriptionPubMed ID: 28571815
dc.description.abstractAs with other organs endometrial functions are altered with the advancing age. Age related decrease in reproductive functions leads to decline in the number of oocytes retrieved and the synthesis of endometrial receptivity molecules. Despite the significant improvement in assisted reproductive technologies we do not have so many options to enhance endometrial receptivity. Due to lack of drugs having endometrium receptivity enhancement properties, oocyte donation seems to be the only solution for women with implantation failure. The euploid oocytes come from young and healthy donors may overcome age associated endometrial receptivity defect. Nevertheless, many reasons restrict us from using oocyte donation in women with implantation failure. We, therefore, hypothesized that by mimicking a young blastocyst's effect on endometrium, the transfer of genuine embryos and implantation-promoting compounds together might be the new treatment option for infertile women with recurrent implantation failure. Artificial beads, MI or GV oocytes, and empty zona can be used as a container for intrauterine replacement of implantation-promoting compounds.
dc.identifier.citationÇelik, Ö., Acet, M., Çelik, S., Şahin, L., Koç, Ö. ve Çelik, N. (2017). Hypothesis: Co-transfer of genuine embryos and implantation promoting compounds via artificial containers improve endometrium receptivity. Medical Hypotheses, 103, 65-70. https://dx.doi.org/10.1016/j.mehy.2017.04.007
dc.identifier.doi10.1016/j.mehy.2017.04.007
dc.identifier.endpage70
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.scopusqualityQ3
dc.identifier.startpage65
dc.identifier.urihttps://dx.doi.org/10.1016/j.mehy.2017.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3410
dc.identifier.volume103
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectArtificial Blastocyst
dc.subjectEndometrium Triggering
dc.subjectImplantation Failure
dc.titleHypothesis: Co-transfer of genuine embryos and implantation promoting compounds via artificial containers improve endometrium receptivity
dc.typeArticle

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