Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group

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dc.authorid0000-0003-1185-9737
dc.contributor.authorAydın, Zeki
dc.contributor.authorTürkmen, Kültigin
dc.contributor.authorDede, Fatih
dc.contributor.authorYaşar, Emre
dc.contributor.authorÖztürk, Savaş
dc.contributor.authorAydın, Mehmet
dc.contributor.authorTatar, Erhan
dc.contributor.authorŞahin, Garip
dc.contributor.authorManga, Gülizar
dc.contributor.authorOto, Özgür
dc.contributor.authorŞumnu, Abdullah
dc.contributor.authorEroğlu, Eray
dc.contributor.authorDinçer, Tamer
dc.contributor.authorDursun, Belda
dc.contributor.authorEren, Necmi
dc.contributor.authorSevinç, Mustafa
dc.contributor.authorGüzel, Fatma Betül
dc.contributor.authorYalın, Serkan
dc.contributor.authorKutlay, Sim
dc.contributor.authorApaydın, Süheyla
dc.contributor.authorBerktaş, Hacı Bayram
dc.contributor.authorKazan, Sinan
dc.contributor.authorDheir, Hamad
dc.contributor.authorBora, Feyza
dc.contributor.authorBaştürk, Taner
dc.contributor.authorŞahin, İdris
dc.date.accessioned2021-03-18T06:34:23Z
dc.date.available2021-03-18T06:34:23Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 +/- 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9-5.7) mg/dl, glomerular filtration rate was 18 (10-37) ml/min/1.73m(2)and proteinuria 2100 (1229-3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.
dc.identifier.citationAydın, Z., Türkmen, K., Dede, F., Yaşar, E., Öztürk, S., Aydın, M. ... Şahin, İ. (2021). Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group. Clinical and Experimental Nephrology, 25(2), 173-183. https://dx.doi.org/10.1007/s10157-020-01978-6
dc.identifier.doi10.1007/s10157-020-01978-6
dc.identifier.endpage183
dc.identifier.issn1342-1751
dc.identifier.issn1437-7799
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage173
dc.identifier.urihttps://dx.doi.org/10.1007/s10157-020-01978-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6614
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical and Experimental Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectRapidly Progressive Glomerulonephritis
dc.subjectAnti-Glomerular Basement Membrane Antibody
dc.subjectImmune Complex Glomerulonephritis
dc.subjectAnti-Neutrophil Cytoplasmic Antibody
dc.titleDemographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
dc.typeArticle

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