Systematic evaluation of drug-loaded hydrogels for application in osteosarcoma treatment

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dc.authorid0000-0001-9052-4411
dc.authorid0000-0002-7794-9308
dc.contributor.authorGümüştaş, Seyit Ali
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorTopuk, Savaş
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖznam, Kadir
dc.contributor.authorOnay, Tolga
dc.contributor.authorOfluoğlu, Önder
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:44Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:44Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionWOS: 000384723200003
dc.descriptionPubMed ID: 27194356
dc.description.abstractThis is a literature review of studies focusing on the preparation of hydrogels for use as oncological drug delivery systems in the treatment of osteosarcoma (OS). The databases of the US National Library of Medicine National Institutes of Health, Embase, OVID, and Cochrane Library, and the references of retrieved studies, were traced from 1843 to December 21, 2015, without language restrictions. The obtained data were evaluated by complementary statistical methods. Potentially relevant studies were found and included in the analysis. OS-specific chemotherapeutic agents can be successfully embedded within the hydrogels and these drug-loaded hydrogels can be applied locally, rather than systemically, without organ tissue toxicity. Further, OS-specific drug-loaded hydrogels significantly increased tumor inhibition and decreased osteolysis and lung metastases. Drug-loaded hydrogels could be useful in the treatment of OS, although their development remains at the experimental phase. Following evaluation of their application in surgery and the completion of drug release kinetics studies, drug-loaded hydrogels could be tested on living mammals in large samples with the aim of applying these in clinical settings. In the future, development of such drug delivery systems and application of targeted approaches against osteosarcoma and other malignancies may render surgery, radiotherapy and chemotherapy unnecessary.
dc.identifier.citationGümüştaş, S. A., İşyar, M., Topuk, S., Yılmaz, İ., Öznam, K., Onay, T. ... Mahiroğulları, M. (2016). Systematic evaluation of drug-loaded hydrogels for application in osteosarcoma treatment. Current Pharmaceutical Biotechnology, 17(10), 866-872. https://dx.doi.org/10.2174/1389201017666160519113104
dc.identifier.doi10.2174/1389201017666160519113104
dc.identifier.endpage872
dc.identifier.issn1389-2010
dc.identifier.issn1873-4316
dc.identifier.issue10
dc.identifier.scopusqualityQ2
dc.identifier.startpage866
dc.identifier.urihttps://dx.doi.org/10.2174/1389201017666160519113104
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2273
dc.identifier.volume17
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectControlled Release
dc.subjectDrug Delivery Systems
dc.subjectHydrogel
dc.subjectSteosarcoma Treatment
dc.titleSystematic evaluation of drug-loaded hydrogels for application in osteosarcoma treatment
dc.typeArticle

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