Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7715-3035
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorLopez, Susanna
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPanerai, Simonetta
dc.contributor.authorCatania, Valentina
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorSalvatore, Marco
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorMassa, Federico
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorBruno, Giuseppe
dc.contributor.authorde Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorYerlikaya, Deniz
dc.contributor.authorTaylor, John Paul
dc.contributor.authorSchumacher, Julia
dc.contributor.authorMckeith, Ian
dc.contributor.authorBonanni, Laura
dc.contributor.authorPantano, Patrizia
dc.contributor.authorPiervincenzi, Claudia
dc.contributor.authorPetsas, Nikolaos
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authordel Percio, Claudio
dc.contributor.authorCarducci, Filippo
dc.date.accessioned2023-09-18T08:11:29Z
dc.date.available2023-09-18T08:11:29Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractHere we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.
dc.identifier.citationBabiloni, C., Lopez, S., Noce, G., Ferri, R., Panerai, S., Catania, V. ... Carducci, F. (2023). Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease. Cerebral Cortex. https://dx.doi.org/10.1093/cercor/bhad300
dc.identifier.doi10.1093/cercor/bhad300
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.pmid37615301
dc.identifier.urihttps://dx.doi.org/10.1093/cercor/bhad300
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11446
dc.identifier.wos001054895600001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherOxford University Press Inc.
dc.relation.ispartofCerebral Cortexen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectStructural Magnetic Resonance Imaging (sMRI)
dc.subjectDefault Mode Network (DMN)
dc.subjectResting State Electroencephalographic (rsEEG) Alpha Rhythms
dc.subjectAlzheimer’s Disease With Dementia (ADD)
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA)
dc.titleRelationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease
dc.typeArticle

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