Parkinson's disease is positively associated with periodontal inflammation

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dc.authorid0000-0003-3435-1856
dc.authorid0000-0001-7986-7085
dc.authorid0000-0001-7409-1484
dc.authorid0000-0002-8811-2263
dc.contributor.authorYılmaz, Melis
dc.contributor.authorYay, Ekin
dc.contributor.authorBalcı, Nur
dc.contributor.authorToygar, Hilal
dc.contributor.authorBolluk Kılıç, Başak
dc.contributor.authorZırh, Ali
dc.contributor.authorRivas, Carla Alvarez
dc.contributor.authorKantarcı, Alpdoğan
dc.date.accessioned2024-02-14T11:04:24Z
dc.date.available2024-02-14T11:04:24Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackgroundParkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden. MethodsWe recruited 60 patients with Stage III, Grade B periodontitis (P) with and without PA (n = 20 for each). We also included systemically and periodontally healthy individuals as controls (n = 20). Clinical periodontal parameters were recorded. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the inflammatory and neurodegenerative targets (YKL-40, fractalkine, S100B, alpha-synuclein, tau, vascular cell adhesion protein-1 (VCAM-1), brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL). ResultsParkinson's patients in this study had mild to moderate motor dysfunctions, which did not prevent them from performing optimal oral hygiene control. Periodontal parameters and GCF volume were significantly higher in the P and P+PA groups than in the control group. PA was associated with significantly increased bleeding on probing (BOP) compared to P-alone (p < 0.05), while other clinical parameters were similar between P and P+PA groups. In saliva and serum, YKL-40 levels were higher in the P+PA group than in P and C groups (p < 0.001). GCF NfL levels from shallow sites were significantly higher in the P+PA group compared to the C group (p = 0.0462). GCF S100B levels from deep sites were higher in the P+PA group than in healthy individuals (p = 0.0194). ConclusionThe data suggested that PA is highly associated with increased periodontal inflammatory burden-bleeding upon probing and inflammatory markers-in parallel with PA-related neuroinflammation.
dc.description.sponsorshipR01AG062496en_US
dc.identifier.citationYılmaz, M., Yay, E., Balcı, N., Toygar, H., Bolluk Kılıç, B., Zırh, A. ... Kantarcı, A. (2023). Parkinson's disease is positively associated with periodontal inflammation. Journal of Periodontology, 94(12), 1425-1435. https://dx.doi.org/10.1002/JPER.23-0274
dc.identifier.doi10.1002/JPER.23-0274
dc.identifier.endpage1435
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue12
dc.identifier.pmid37433175
dc.identifier.scopus2-s2.0-85164780497
dc.identifier.scopusqualityQ1
dc.identifier.startpage1425
dc.identifier.urihttps://dx.doi.org/10.1002/JPER.23-0274
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12277
dc.identifier.volume94
dc.identifier.wos001023555400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Melis
dc.institutionauthorYay, Ekin
dc.institutionauthorBalcı, Nur
dc.institutionauthorToygar, Hilal
dc.institutionauthorBolluk Kılıç, Başak
dc.institutionauthorZırh, Ali
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEtiology
dc.subjectInflammation
dc.subjectParkinson’s Disease
dc.subjectPeriodontitis
dc.subjectSaliva
dc.titleParkinson's disease is positively associated with periodontal inflammation
dc.typeArticle

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