Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authordel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorCatania, Valentine
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorBonanni, Laura
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorFraioli, Lucia
dc.contributor.authorParnetti, Lucilla
dc.contributor.authorFarotti, Lucia
dc.contributor.authorPievani, Michela
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorde Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorMcKeith, Ian
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorde Pandis, Maria Francesca
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:55Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000450412900002
dc.descriptionPubMed ID: 30312790
dc.description.abstractWe hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.
dc.description.sponsorshipH2020 Marie S. Curie ITN-ETN projecten_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title " BBDiag" (http://bbdiag-itnetn.eu).The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.en_US
dc.identifier.citationBabiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. … de Pandis, M. F. (2019). Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms. Neurobiology of Aging, 73, 9-20. https://dx.doi.org/10.1016/j.neurobiolaging.2018.08.010
dc.identifier.doi10.1016/j.neurobiolaging.2018.08.010
dc.identifier.endpage20
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.scopusqualityQ1
dc.identifier.startpage9
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2018.08.010
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1819
dc.identifier.volume73
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFunctional Brain Connectivity
dc.subjectResting State EEG Rhythms
dc.subjectMild Cognitive Impairment Due To Alzheimer's Disease (ADMCI)
dc.subjectMild Cognitive Impairment Due To Parkinson's Disease (PDMCI)
dc.titleLevodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms
dc.typeArticle

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